TFactS Manual

CONTENTS:

  1. DESCRIPTION
  2. AUTHORS
  3. INPUT
    1. TFactS MODES
    2. Supported organisms
    3. Gene specification
  4. ANNOTATED SIGNATURES
    1. Data sources
    2. Target gene signatures
  5. METHOD
    1. Comparison Statistics
    2. Statistical significance
    3. Example
  6. PUBLICATIONS
  7. ACKNOWLEDGEMENTS
  8. REFERENCES


DESCRIPTION

is designed to predict which transcription factors are regulated, inhibited or activated in a biological system based on lists of upregulated and downregulated genes generated in microarray experiments.
TFactS takes as input lists of up- and/or down-regulated genes (query genes), compares it with a catalogue of annotated target genes, and returns three lists of transcription factors whose annotated target genes show a significant overlap with the query genes. The first list shows the Regulated Transcription Factors(TF) using the the Sign-Less catalogue, the second list shows the activated TF and the third list shows the Respressed TF. Both the activated and repressed lists are produced using the Sign-Sensitive catalogue.

AUTHORS

Ahmed Essaghir & Jean-Baptiste Demoulin

INPUT

TFactS MODES:

TFactS can be used in 2 modes (Batch Mode and Simple Mode):
  1. BatchTFactS is made to simplify multiple submissions:
  2. TFactS (Simple Mode) takes as input one or two lists of query genes:
  3. The user can specify which catalogue to use. "Add Data" button can be used to sepcify costum catalogues.
  4. The user can specify how many random selection to use for negative control (RC : see Methods section)
  5. The user can specify desired thresholds for positive control and False discovery control (see Methods section)
  6. The user can limit the comparison list of TFs to the ones having more than a certain number of target genes (target gene # threshold)

Supported organisms:

TFactS primarily aims at interpreting human data. Rat and mouse human orthologue genes are also supported.

Gene specification:

genes should be specified by their HGNC official names or by their Entrez ids.

ANNOTATED SIGNATURES

TFactS relies on catalogues of transcription factor signatures. A signature is defined here as the list of genes regulated by a transcription factor.
The Sign-Sensitive catalogue enumerates pairwise relationships between transcription factors (TF) and their target genes (TG), documented with the regulation type (up or down). The Sign-Less catalogue doesnt contain regulation type information.

Data sources

Lists of TG are obtained from literature (see references) and databases like , , curated and . We annotated some of these lists with the regulation type (up or down) based on the original publications (from PubMed). SREBP and p53 TG were based on our previous reports[1,2] and were complemented by data in TRED with the regulation type from original publications. The FOXOs and STATs transcription factors TG lists were built from published papers[3-21].

Target gene signatures

In our catalogue of TF target genes , we define a signature as a set of all the target genes of this TF. And a Generic TF is defined as a TF representing a very close family of transcription factors: STAT, e.g, is a Generic TF for STAT1, STAT3 and STAT5.

Specific signatures

A Specific Signature is the normal signature as defined above for each TF.

Generic signatures

A Generic Signature is the union of all Specific signatures of the TF represented as a Generic transcription factor.

METHOD

The program compares the list(s) of query genes (up and/or down) with a catalogue of signatures.

Comparison Statistics

For each TF Three hypotheses are tested using a contingency table as follows :

TFUser: PresentUser: AbsentTotal
Catalogue: Presentkm-km
Catalogue: Absentn-kN+k-n-mN-m
TotalnN-nN

m: # TG of TF
n: # submitted genes
N: # signatures in the catalogue
k differs according to the hypothesis to be tested as follows :

Statistical significance

TFacts gives as output three tables, each table gives statistics for each of the three hypotheses (Regulation (sign-less catalogue), Activation and Repression (sign-sentisitve catalogue) of a TF)

Example

Total Submitted genes (UP + DOWN): 43;
FOXO3 has 66 TG in the sign-sensitive catalogue;
among the submitted genes, 11 matched FOXO3 TG;
among these 11 genes : 8 matched the regulation type and 3 mismatched the regulation type.
Total number of Tests : 24;
Number of Repetitions (random simulation): 100;

Activation of FOXO3
FOXO3User: PresentUser: AbsentTotal
Catalogue: Present85866
Catalogue: Absent3523282363
Total4323862429
  1. P-value = 1.40e-4;
  2. E-value = 3.36e-3;
  3. Q-value = 3.36e-3;
  4. FDR control = 2.08e-3 (≥ P-value);
  5. RC ≤1%

Repression of FOXO3
FOXO3User: PresentUser: AbsentTotal
Catalogue: Present36366
Catalogue: Absent4023232363
Total4323862429
  1. P-value = 2.15e-1;
  2. E-value = 5.15e+0;
  3. Q-value = 3.06e-1;
  4. FDR control = 1.67e-2 (< P-value);
  5. RC ≤1%

If we set thresholds like : P-value ≤ 0.05; E-value ≤ 0.05; Q-value ≤ 0.05; FDR ≤ 0.05 and RC ≤ 5% Then we can say that FOXO3 is activated in this system.
The regulation hypothesis is based on the sign-less catalogue and the contingency table is built as the same as above without taking into account the sign of the regulations.

PUBLICATIONS

Essaghir A, Toffalini F, Knoops L, Kallin A, van Helden J, Demoulin JB: Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data. Nucleic Acids Res. 2010 Jun 1;38(11):e120. Epub 2010 Mar 9.

ACKNOWLEDGEMENTS

REFERENCES

  1. Demoulin JB, Ericsson J, Kallin A, Rorsman C, Rönnstrand L, Heldin CH: Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding pro-teins. J Biol Chem 2004, 279(34):35392-35402.
  2. Knoops L, Haas R, de Kemp S, Majoor D, Broeks A, Eldering E, de Boer JP, Verheij M, van Ostrom C, de Vries A, van't Veer L, de Jong D: In vivo p53 response and immune reaction underlie highly ective low-dose radiotherapy in follicular lymphoma. Blood 2007, 110(4):1116-1122.
  3. Buzzio OL, Lu Z, Miller CD, Unterman TG, Kim JJ: FOXO1A differentially regulates genes of decidualization. Endocrinology 2006, 147(8):3870-3876.
  4. Kim JJ, Buzzio OL, Li S, Lu Z: Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor. Biol Reprod 2005, 73(4):833-839.
  5. Kyoung KH, Kyoung KY, Song IH, Baek SH, Lee SR, Hye KJ, Kim JR: Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci 2005, 60:4-9.
  6. Liu JW, Chandra D, Rudd MD, Butler AP, Pallotta V, Brown D, Coffer PJ, Tang D: Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene 2005, 24(12):2020-2031.
  7. Alikhani M, Alikhani Z, Graves DT: FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem 2005, 280(13):12096-12102.
  8. Kim JJ, Fazleabas AT: Uterine receptivity and im-plantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium. Reprod Biol Endocrinol 2004, 16:2-34.
  9. Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, Burgering BM, Medema RH: Cell cycle inhibition by FoxO forkhead transcription factors involves downregula-tion of cyclin D. Mol Cell Biol 2002, 22(22):7842-7852.
  10. Modur V, Nagarajan R, Evers BM, Milbrandt J: FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implica-tions for PTEN mutation in prostate cancer. J Biol Chem 2002, 277(49):47928-47937.
  11. Kamei Y, Mizukami J, Miura S, Suzuki M, Takahashi N, Kawada T, Taniguchi T, Ezaki O: A forkhead tran-scription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle. FEBS Lett 2003, 536(1-3):232-236.
  12. Kim JJ, Taylor HS, Akbas GE, Foucher I, Trembleau A, Jaffe RC, Fazleabas AT, Unterman TG: Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Biol Reprod 2003, 68:24-30.
  13. Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, Lam EW, Burgering BM, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ: Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol 2000, 20(24):9138-9148.
  14. Matsumoto M, Han S, Kitamura T, Accili D: Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 2006, 116(9):2464-2472.
  15. Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, Kim KS, Kim SW, Kim HS, Park JY, Kim YB, Lee KU: Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci 2006, 9(7):901-907.
  16. Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM: Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes 2006, 55(7):2042-2050.
  17. Tomida M, Ohtake H, Yokota T, Kobayashi Y, Kurosumi M: Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. J Cancer Res Clin Oncol 2008, 134(5):551-559.
  18. Song H, Jin X, Lin J: Stat3 upregulates MEK5 expression in human breast cancer cells. Oncogene 2004, 23(50):8301-8309.
  19. Bhattacharya S, Ray RM, Johnson LR: STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. Biochem J 2005, 392(Pt2):335-344.
  20. Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002, 21(13):2000-2008.
  21. Clarkson RW, Boland MP, Kritikou EA, Lee JM, Freeman TC, Tiffen PG, Watson CJ: The genes induced by signal transducer and activators of transcription STAT3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Mol Endocrinol 2006, 20(3):675-685.
  22. Storey JD: A direct approach to false discovery rates. Journal of the Royal Statistical Society 2002, 64: 479-498.
  23. Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci 2003, 100:9440-9445
  24. Storey JD, Taylor JE, and Siegmund D: Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: A unified approach. Journal of the Royal Statistical Society 2004, 66: 187-205.
  25. Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society 1995, 57: 289-300.
  26. Abramovitch, R., Tavor, E., Jacob-Hirsch, J., Zeira, E., Amariglio, N., Pappo, O., Rechavi, G., Galun, E. & Honigman, A. A pivotal role of cyclic AMP-responsive element binding protein in tumor progression. Cancer Res, Goldyne Savad Institute of Gene Therapy, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., 2004, Vol. 64(4), pp. 1338-1346
  27. Agoulnik, I.U., Vaid, A., Nakka, M., Alvarado, M., Bingman, W.E., Erdem, H., Frolov, A., Smith, C.L., Ayala, G.E., Ittmann, M.M. & Weigel, N.L. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., 2006, Vol. 66(21), pp. 10594-10602
  28. Agren, M., Kogerman, P., Kleman, M.I., Wessling, M. & Toftgård, R. Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene, Department of Bioscience at NOVUM, Center for Nutrition and Toxicology, Karolinska Institute, Huddinge 141 57, Sweden., 2004, Vol. 330, pp. 101-114
  29. Akiyoshi, T., Nakamura, M., Koga, K., Nakashima, H., Yao, T., Tsuneyoshi, M., Tanaka, M. & Katano, M. Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. Gut, Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan., 2006, Vol. 55(7), pp. 991-999
  30. i Altaba, A.R. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development, The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA. ria@saturn.med.nyu.edu, 1998, Vol. 125(12), pp. 2203-2212 article(Alvarez-Medina2008) Alvarez-Medina, R., Cayuso, J., Okubo, T., Takada, S. & Martí, E. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development, Instituto de Biología Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, C/Josep Samitier 1-5, Barcelona 08028, Spain., 2008, Vol. 135(2), pp. 237-247
  31. Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T. & Flavell, R.A. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. d.amsen@amc.uva.nl, 2007, Vol. 27(1), pp. 89-99
  32. Anthony, T.E., Mason, H.A., Gridley, T., Fishell, G. & Heintz, N. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev, Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA., 2005, Vol. 19(9), pp. 1028-1033
  33. Araki, Y., Okamura, S., Hussain, S.P., Nagashima, M., He, P., Shiseki, M., Miura, K. & Harris, C.C. Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. Cancer Res, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., 2003, Vol. 63(3), pp. 728-734
  34. Arnold, S.J., Stappert, J., Bauer, A., Kispert, A., Herrmann, B.G. & Kemler, R. Brachyury is a target gene of the Wnt/beta-catenin signaling pathway. Mech Dev, Max-Planck Institut für Immunbiologie, Stübeweg 51, D-79108, Freiburg, Germany., 2000, Vol. 91(1-2), pp. 249-258
  35. ichi Asaka, J., Terada, T., Okuda, M., Katsura, T. & ichi Inui, K. Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3. Pharm Res, Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan., 2006, Vol. 23(4), pp. 697-704
  36. Asirvatham, A.J., Carey, J.P.W. & Chaudhary, J. ID1-, ID2-, and ID3-regulated gene expression in E2A positive or negative prostate cancer cells. Prostate, Department of Biology, Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta, Georgia 30314, USA., 2007, Vol. 67(13), pp. 1411-1420
  37. Baker, J.C., Beddington, R.S. & Harland, R.M. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA., 1999, Vol. 13(23), pp. 3149-3159
  38. Balbín, M. & López-Otín, C. Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone. J Biol Chem, Departamento de Biología Funcional, Universidad de Oviedo, 33006 Oviedo, Spain., 1996, Vol. 271(25), pp. 15175-15181
  39. Balciunaite, G., Keller, M.P., Balciunaite, E., Piali, L., Zuklys, S., Mathieu, Y.D., Gill, J., Boyd, R., Sussman, D.J. & Holländer, G.A. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol, Pediatric Immunology, Department of Research and Clinical-biological Sciences, and the Children's Hospital, University of Basel, Basel, Switzerland., 2002, Vol. 3(11), pp. 1102-1108
  40. Baniwal, S.K., Khalid, O., Sir, D., Buchanan, G., Coetzee, G.A. & Frenkel, B. Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA. Mol Endocrinol, Department Biochemistry and Molecular Biology, Institute of Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA., 2009, Vol. 23(8), pp. 1203-1214
  41. Bash, J., Zong, W.X., Banga, S., Rivera, A., Ballard, D.W., Ron, Y. & Gélinas, C. Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854-5638, USA., 1999, Vol. 18(10), pp. 2803-2811
  42. Bataille, F., Rogler, G., Modes, K., Poser, I., Schuierer, M., Dietmaier, W., Ruemmele, P., Mühlbauer, M., Wallner, S., Hellerbrand, C. & Bosserhoff, A.-K. Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin. Lab Invest, Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany., 2005, Vol. 85(1), pp. 124-136
  43. Batlle, E., Henderson, J.T., Beghtel, H., van den Born, M.M.W., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T. & Clevers, H. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell, edical Genetics, University Medical Center, Utrecht, The Netherlands., 2002, Vol. 111(2), pp. 251-263
  44. Benson, R.A., Adamson, K., Corsin-Jimenez, M., Marley, J.V., Wahl, K.A., Lamb, J.R. & Howie, S.E.M. Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production. Eur J Immunol, Immunobiology Group, Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK. rbenson@staffmail.ed.ac.uk, 2005, Vol. 35(3), pp. 859-869
  45. Bessho, Y., Miyoshi, G., Sakata, R. & Kageyama, R. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan., 2001, Vol. 6(2), pp. 175-185
  46. Bhattacharya, R., Kwon, J., Ali, B., Wang, E., Patra, S., Shridhar, V. & Mukherjee, P. Role of hedgehog signaling in ovarian cancer. Clin Cancer Res, Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. bhattacharya.resham@mayo.edu, 2008, Vol. 14(23), pp. 7659-7666
  47. Bianchi, N., Depianto, D., McGowan, K., Gu, C. & Coulombe, P.A. Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Mol Cell Biol, Predoctoral Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 212105, USA., 2005, Vol. 25(16), pp. 7249-7259
  48. Bigelow, R.L.H., Chari, N.S., Unden, A.B., Spurgers, K.B., Lee, S., Roop, D.R., Toftgard, R. & McDonnell, T.J. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem, Department of Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA., 2004, Vol. 279(2), pp. 1197-1205
  49. Bonifas, J.M., Pennypacker, S., Chuang, P.T., McMahon, A.P., Williams, M., Rosenthal, A., Sauvage, F.J.D. & Epstein, E.H. Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol, Department of Dermatology, San Francisco General Hospital, California, USA., 2001, Vol. 116(5), pp. 739-742
  50. Boon, E.M.J., van der Neut, R., van de Wetering, M., Clevers, H. & Pals, S.T. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res, Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands., 2002, Vol. 62(18), pp. 5126-5128
  51. Borello, U., Berarducci, B., Murphy, P., Bajard, L., Buffa, V., Piccolo, S., Buckingham, M. & Cossu, G. The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development, Stem Cell Research Institute, Dibit, H. San Raffaele, Via Olgettina 58, 20132 Milan, Italy. ugo.borello@ucsf.edu, 2006, Vol. 133(18), pp. 3723-3732
  52. Borycki, A.G., Mendham, L. & Emerson, C.P. Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development, Department of Cell and Developmental Biology, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA., 1998, Vol. 125(4), pp. 777-790
  53. Brabletz, T., Jung, A., Dag, S., Hlubek, F. & Kirchner, T. beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol, Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany. thomas.brabletz@patho.med.uni-erlangen.de, 1999, Vol. 155(4), pp. 1033-1038
  54. Brancaccio, A., Minichiello, A., Grachtchouk, M., Antonini, D., Sheng, H., Parlato, R., Dathan, N., Dlugosz, A.A. & Missero, C. Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis. Hum Mol Genet, Telethon Institute of Genetics and Medicine (TIGEM), via Pietro Castellino 111, 80131 Napoli, Italy., 2004, Vol. 13(21), pp. 2595-2606
  55. Brewster, R. & i Altaba, A.R. Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS. Mech Dev, The Skirball Institute, Developmental Genetics Program, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA., 2000, Vol. 99(1-2), pp. 159-162
  56. Brum, I.S., Morsch, D.M., Pozzobon, A., Boeri, V.A., Geib, G. & Spritzer, P.M. Androgen-dependent expression of c-jun and c-fos in human non-transformed epithelial prostatic cells: association with cell proliferation. Horm Res, siology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. ilma@vortex.ufrgs.br, 2003, Vol. 60(5), pp. 209-214
  57. Bénazéraf, B., Chen, Q., Peco, E., Lobjois, V., Médevielle, F., Ducommun, B. & Pituello, F. Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B. Dev Biol, Centre de Biologie du Développement, UMR5547 CNRS-Université P. Sabatier, IFR109--Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, 31062 Toulouse Cedex, France., 2006, Vol. 294(1), pp. 133-147
  58. Büscher, D. & Rüther, U. Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev Dyn, Institut für Molekularbiologie, Medizinische Hochschule Hannover, Germany., 1998, Vol. 211(1), pp. 88-96
  59. Callahan, C.A., Ofstad, T., Horng, L., Wang, J.K., Zhen, H.H., Coulombe, P.A. & Oro, A.E. MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev, Program in Epithelial Biology and Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA., 2004, Vol. 18(22), pp. 2724-2729
  60. Campbell, P.M. & Szyf, M. Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. Carcinogenesis, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6., 2003, Vol. 24(1), pp. 17-24
  61. Carter, N., Lönnerholm, G., Meyerson, B. & Wistrand, P. Androgen-linked control of carbonic anhydrase III expression occurs in rat perivenous hepatocytes; an immunocytochemical study. Ups J Med Sci, Medical Genetics Unit, St. George's Hospital Medical School, London, United Kingdom., 2001, Vol. 106(1), pp. 67-76 article(Castelo-Branco2003) Castelo-Branco, G., Wagner, J., Rodriguez, F.J., Kele, J., Sousa, K., Rawal, N., Pasolli, H.A., Fuchs, E., Kitajewski, J. & Arenas, E. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A, Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171-77 Stockholm, Sweden., 2003, Vol. 100(22), pp. 12747-12752
  62. Chakladar, A., Dubeykovskiy, A., Wojtukiewicz, L.J., Pratap, J., Lei, S. & Wang, T.C. Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment. Biochem Biophys Res Commun, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., 2005, Vol. 336(1), pp. 190-196
  63. Chamorro, M.N., Schwartz, D.R., Vonica, A., Brivanlou, A.H., Cho, K.R. & Varmus, H.E. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J, Cancer Biology and Genetics Program, Sloan-Kettering Institute, Varmus Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA., 2005, Vol. 24(1), pp. 73-84
  64. Chang, D., Valdez, P., Ho, T. & Robey, E. MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment. J Immunol, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA., 2000, Vol. 165(12), pp. 6710-6715
  65. Chen, H., Chong, Y. & Liu, C.L. Active intracellular domain of Notch enhances transcriptional activation of CCAAT/enhancer binding protein beta on a rat pregnancy-specific glycoprotein gene. Biochemistry, Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan, and Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 10098, Taiwan. hwchen@gate.sinica.edu.tw, 2000, Vol. 39(7), pp. 1675-1682
  66. Chen, M., Chen, L.-M. & Chai, K.X. Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. Prostate, Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida 32816-2364, USA., 2006, Vol. 66(9), pp. 911-920
  67. Chen, P.-H., Tsao, Y.-P., Wang, C.-C. & Chen, S.-L. Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability. Nucleic Acids Res, Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan., 2008, Vol. 36(1), pp. 51-66
  68. Chen, T., Yang, I., Irby, R., Shain, K.H., Wang, H.G., Quackenbush, J., Coppola, D., Cheng, J.Q. & Yeatman, T.J. Regulation of caspase expression and apoptosis by adenomatous polyposis coli. Cancer Res, Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA., 2003, Vol. 63(15), pp. 4368-4374
  69. Chen, Y., Fischer, W.H. & Gill, G.N. Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem, Department of Medicine, University of California San Diego, La Jolla, California 92093-0650, USA., 1997, Vol. 272(22), pp. 14110-14114
  70. Cheng, P., Zlobin, A., Volgina, V., Gottipati, S., Osborne, B., Simel, E.J., Miele, L. & Gabrilovich, D.I. Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA., 2001, Vol. 167(8), pp. 4458-4467
  71. Chtarbova, S., Nimmrich, I., Erdmann, S., Herter, P., Renner, M., Kitajewski, J. & Müller, O. Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. Biochem J, Arbeitsgruppe Tumorgenetik, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany., 2002, Vol. 367(Pt 3), pp. 723-728
  72. Clegg, N., Eroglu, B., Ferguson, C., Arnold, H., Moorman, A. & Nelson, P.S. Digital expression profiles of the prostate androgen-response program. J Steroid Biochem Mol Biol, Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA., 2002, Vol. 80(1), pp. 13-23
  73. Clifford, R.L., Deacon, K. & Knox, A.J. Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta). J Biol Chem, Centre for Respiratory Research, Clinical Sciences Building, University of Nottingham, Nottingham NG5 1PB, United Kingdom., 2008, Vol. 283(51), pp. 35337-35353 article(Conacci-Sorrell2002) Conacci-Sorrell, M.E., Ben-Yedidia, T., Shtutman, M., Feinstein, E., Einat, P. & Ben-Ze'ev, A. Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev, Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel., 2002, Vol. 16(16), pp. 2058-2072
  74. Crawford, H.C., Fingleton, B.M., Rudolph-Owen, L.A., Goss, K.J., Rubinfeld, B., Polakis, P. & Matrisian, L.M. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2175, USA., 1999, Vol. 18(18), pp. 2883-2891
  75. Cui, C., Elsam, T., Tian, Q., Seykora, J.T., Grachtchouk, M., Dlugosz, A. & Tseng, H. Gli proteins up-regulate the expression of basonuclin in Basal cell carcinoma. Cancer Res, Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., 2004, Vol. 64(16), pp. 5651-5658
  76. Cyr, D.G., Dufresne, J., Pillet, S., Alfieri, T.J. & Hermo, L. Expression and regulation of metallothioneins in the rat epididymis. J Androl, Centre de Recherches en Santé Humaine, INRS-Institut Armand Frappier, Université du Québec, Pointe Claire, Canada. daniel.cyr@inrs-sante.uquebec.ca, 2001, Vol. 22(1), pp. 124-135 article(D'Amico2000) D'Amico, M., Hulit, J., Amanatullah, D.F., Zafonte, B.T., Albanese, C., Bouzahzah, B., Fu, M., Augenlicht, L.H., Donehower, L.A., Takemaru, K., Moon, R.T., Davis, R., Lisanti, M.P., Shtutman, M., Zhurinsky, J., Ben-Ze'ev, A., Troussard, A.A., Dedhar, S. & Pestell, R.G. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem, Albert Einstein Cancer Center, Departments of Developmental and Molecular Biology Medicine and Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA., 2000, Vol. 275(42), pp. 32649-32657
  77. Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. & Ishii, S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem, Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan., 1999, Vol. 274(12), pp. 8143-8152
  78. Dai, P., Shinagawa, T., Nomura, T., Harada, J., Kaul, S.C., Wadhwa, R., Khan, M.M., Akimaru, H., Sasaki, H., Colmenares, C. & Ishii, S. Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev, Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Ibaraki, Japan., 2002, Vol. 16(22), pp. 2843-2848
  79. Davey, M.G., James, J., Paton, I.R., Burt, D.W. & Tickle, C. Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature. Dev Biol, Division of Cell and Developmental Biology, WTB, University of Dundee, Dundee, UK., 2007, Vol. 301(1), pp. 155-165
  80. Deftos, M.L., He, Y.W., Ojala, E.W. & Bevan, M.J. Correlating notch signaling with thymocyte maturation. Immunity, Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA., 1998, Vol. 9(6), pp. 777-786
  81. Deftos, M.L., Huang, E., Ojala, E.W., Forbush, K.A. & Bevan, M.J. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity, Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA., 2000, Vol. 13(1), pp. 73-84
  82. Dentice, M., Luongo, C., Huang, S., Ambrosio, R., Elefante, A., Mirebeau-Prunier, D., Zavacki, A.M., Fenzi, G., Grachtchouk, M., Hutchin, M., Dlugosz, A.A., Bianco, A.C., Missero, C., Larsen, P.R. & Salvatore, D. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A, Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy, and Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA., 2007, Vol. 104(36), pp. 14466-14471
  83. Denys, H., Jadidizadeh, A., Nik, S.A., Dam, K.V., Aerts, S., Alman, B.A., Cassiman, J.-J. & Tejpar, S. Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. Oncogene, Center for Human Genetics, University of Leuven, Leuven B-3000, Belgium., 2004, Vol. 23(3), pp. 654-664
  84. Dihlmann, S., Kloor, M., Fallsehr, C. & von Knebel Doeberitz, M. Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis, Institute of Molecular Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany. susanne.dihlmann@med.uni-heidelberg.de, 2005, Vol. 26(9), pp. 1503-1512
  85. Dimberg, J., Hugander, A., Sirsjö, A. & Söderkvist, P. Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer. Anticancer Res, Department of Biomedicine and Surgery, Division of Cell Biology, Faculty of Health Sciences, Linköping, Sweden. jan.dimberg@hhj.hj.se, 2001, Vol. 21(2A), pp. 911-915
  86. Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. & Hui, C.C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development, ntario M5G 1X8, Canada., 1998, Vol. 125(14), pp. 2533-2543 article(Domon-Dell2002) Domon-Dell, C. & Freund, J.-N. Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein. FEBS Lett, Institut National de la Santé et de la Recherche Médicale, Unité 381, 3 avenue Molière, 67200, Strasbourg, France., 2002, Vol. 518(1-3), pp. 83-87
  87. Dong, Y.-F., Soung, D.Y., Schwarz, E.M., O'Keefe, R.J. & Drissi, H. Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J Cell Physiol, Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA., 2006, Vol. 208(1), pp. 77-86
  88. Driskell, R.R., Goodheart, M., Neff, T., Liu, X., Luo, M., Moothart, C., Sigmund, C.D., Hosokawa, R., Chai, Y. & Engelhardt, J.F. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol, Department of Anatomy and Cell Biology, Iowa City, IA 52242, USA., 2007, Vol. 305(1), pp. 90-102
  89. Du, Q., Park, K.S., Guo, Z., He, P., Nagashima, M., Shao, L., Sahai, R., Geller, D.A. & Hussain, S.P. Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA., 2006, Vol. 66(14), pp. 7024-7031
  90. Dutton, J.R., Antonellis, A., Carney, T.J., Rodrigues, F.S.L.M., Pavan, W.J., Ward, A. & Kelsh, R.N. An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10. BMC Dev Biol, Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK. dutto015@umn.edu, 2008, Vol. 8, pp. 105
  91. Easwaran, V., Lee, S.H., Inge, L., Guo, L., Goldbeck, C., Garrett, E., Wiesmann, M., Garcia, P.D., Fuller, J.H., Chan, V., Randazzo, F., Gundel, R., Warren, R.S., Escobedo, J., Aukerman, S.L., Taylor, R.N. & Fantl, W.J. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res, Chiron Corporation, Emeryville, California 94608, USA., 2003, Vol. 63(12), pp. 3145-3153
  92. Eichberger, T., Kaser, A., Pixner, C., Schmid, C., Klingler, S., Winklmayr, M., Hauser-Kronberger, C., Aberger, F. & Frischauf, A.-M. GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Austria., 2008, Vol. 283(18), pp. 12426-12437
  93. Eichberger, T., Regl, G., Ikram, M.S., Neill, G.W., Philpott, M.P., Aberger, F. & Frischauf, A.-M. FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. J Invest Dermatol, Department of Molecular Biology, University of Salzburg, Salzburg, Austria., 2004, Vol. 122(5), pp. 1180-1187
  94. Elagib, K.E., Xiao, M., Hussaini, I.M., Delehanty, L.L., Palmer, L.A., Racke, F.K., Birrer, M.J., Shanmugasundaram, G., McDevitt, M.A. & Goldfarb, A.N. Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2. Mol Cell Biol, University of Virginia School of Medicine, P.O. Box 800904, Charlottesville, VA 22908, USA., 2004, Vol. 24(17), pp. 7779-7794
  95. Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V., Jessell, T.M. & Briscoe, J. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell, Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA., 1997, Vol. 90(1), pp. 169-180
  96. Faraldo, M.M., Teulière, J., Deugnier, M.-A., Birchmeier, W., Huelsken, J., Thiery, J.P., Cano, A. & Glukhova, M.A. beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells. FEBS Lett, aldo@curie.fr, 2007, Vol. 581(5), pp. 831-836
  97. Friedman, M.S., Oyserman, S.M. & Hankenson, K.D. Wnt11 Promotes Osteoblast Maturation and Mineralization through R-spondin 2. J Biol Chem, ThermoGenesis Corporation, Rancho Cordova, California 95742., 2009, Vol. 284(21), pp. 14117-14125
  98. Fujimura, N., Vacik, T., Machon, O., Vlcek, C., Scalabrin, S., Speth, M., Diep, D., Krauss, S. & Kozmik, Z. Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. J Biol Chem, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic., 2007, Vol. 282(2), pp. 1225-1237
  99. Fujita, M., Furukawa, Y., Nagasawa, Y., Ogawa, M. & Nakamura, Y. Down-regulation of monocyte chemotactic protein-3 by activated beta-catenin. Cancer Res, ry of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan., 2000, Vol. 60(23), pp. 6683-6687
  100. Fujita, M., Furukawa, Y., Tsunoda, T., Tanaka, T., Ogawa, M. & Nakamura, Y. Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. Cancer Res, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., 2001, Vol. 61(21), pp. 7722-7726
  101. Furumoto, T.A., Miura, N., Akasaka, T., Mizutani-Koseki, Y., Sudo, H., Fukuda, K., Maekawa, M., Yuasa, S., Fu, Y., Moriya, H., Taniguchi, M., Imai, K., Dahl, E., Balling, R., Pavlova, M., Gossler, A. & Koseki, H. Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev Biol, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan., 1999, Vol. 210(1), pp. 15-29
  102. Galceran, J., Sustmann, C., Hsu, S.-C., Folberth, S. & Grosschedl, R. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev, Gene Center and Institute of Biochemistry, University of Munich, 81377 Munich, Germany., 2004, Vol. 18(22), pp. 2718-2723
  103. Ganesan, K., Ivanova, T., Wu, Y., Rajasegaran, V., Wu, J., Lee, M.H., Yu, K., Rha, S.Y., Chung, H.C., Ylstra, B., Meijer, G., Lian, K.O., Grabsch, H. & Tan, P. Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene. Cancer Res, Cellular and Molecular Research, National Cancer Center, Genome Institute of Singapore, Singapore, Singapore., 2008, Vol. 68(11), pp. 4277-4286
  104. Gao, S., Wang, H., Lee, P., Melamed, J., Li, C.X., Zhang, F., Wu, H., Zhou, L. & Wang, Z. Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J Mol Endocrinol, Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., 2006, Vol. 36(3), pp. 463-483
  105. Gaur, T., Lengner, C.J., Hovhannisyan, H., Bhat, R.A., Bodine, P.V.N., Komm, B.S., Javed, A., van Wijnen, A.J., Stein, J.L., Stein, G.S. & Lian, J.B. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem, Department of Cell Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0106, USA., 2005, Vol. 280(39), pp. 33132-33140
  106. Gavert, N., Conacci-Sorrell, M., Gast, D., Schneider, A., Altevogt, P., Brabletz, T. & Ben-Ze'ev, A. L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol, 76100, Israel., 2005, Vol. 168(4), pp. 633-642
  107. Ghiselli, G. & Agrawal, A. The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. Biochem J, Department of Pathology and Cell Biology, Thomas Jefferson University, 1020 Locust Street, JAH 371, Philadelphia, PA 19107, USA. Giancarlo.Ghiselli@jefferson.edu, 2005, Vol. 390(Pt 2), pp. 493-499
  108. Ghiselli, G., Coffee, N., Munnery, C.E., Koratkar, R. & Siracusa, L.D. The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J Biol Chem, Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. giancarlo.ghiselli@mail.tju.edu, 2003, Vol. 278(22), pp. 20259-20267
  109. Gilles, C., Polette, M., Mestdagt, M., Nawrocki-Raby, B., Ruggeri, P., Birembaut, P. & Foidart, J.-M. Transactivation of vimentin by beta-catenin in human breast cancer cells. Cancer Res, Laboratory of Tumor and Developmental Biology, University of Liège, CHU Sart-Tilman, B23, B-4000 Liège, Belgium. cgilles@ulg.ac.be, 2003, Vol. 63(10), pp. 2658-2664 article(Gonzalez-Sancho2005) González-Sancho, J.M., Aguilera, O., García, J.M., Pendás-Franco, N., Peña, C., Cal, S., de Herreros, A.G., Bonilla, F. & Muñoz, A. The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Arturo Duperier 4, E-28029 Madrid, Spain., 2005, Vol. 24(6), pp. 1098-1103
  110. Gonçalves, V., Matos, P. & Jordan, P. The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA, Centro de Genética Humana, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal., 2008, Vol. 14(12), pp. 2538-2549
  111. Gradl, D., Kühl, M. & Wedlich, D. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol, Department of Biochemistry, University of Ulm, D-89081 Ulm, Germany., 1999, Vol. 19(8), pp. 5576-5587
  112. Green, J., Leigh, I.M., Poulsom, R. & Quinn, A.G. Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1. Br J Dermatol, Centre for Cutaneous Research, St Bartholomew's and The Royal London Hospital School of Medicine and Dentistry, 2 Newark Street, Whitechapel, London E1 2AT, U.K., 1998, Vol. 139(5), pp. 911-915
  113. Gummow, B.M., Winnay, J.N. & Hammer, G.D. Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene. J Biol Chem, Department of Molecular and Integrative Physiology, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109, USA., 2003, Vol. 278(29), pp. 26572-26579
  114. Gustafsson, M.K., Pan, H., Pinney, D.F., Liu, Y., Lewandowski, A., Epstein, D.J. & Emerson, C.P. Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA., 2002, Vol. 16(1), pp. 114-126
  115. Gustavson, M.D., Crawford, H.C., Fingleton, B. & Matrisian, L.M. Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters. Mol Carcinog, Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232-6840, USA., 2004, Vol. 41(3), pp. 125-139
  116. Hamada, S., Watanabe, K., Hirota, M., Bianco, C., Strizzi, L., Mancino, M., Gonzales, M. & Salomon, D.S. beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. Biochem Biophys Res Commun, Mammary Biology and Tumorigenesis Laboratory, NCI/CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA., 2007, Vol. 355(1), pp. 240-244
  117. He, J., Sheng, T., Stelter, A.A., Li, C., Zhang, X., Sinha, M., Luxon, B.A. & Xie, J. Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J Biol Chem, Sealy Center for Cancer Cell Biology, Department of Pharmacology and Biochemistry, University of Texas Medical Branch, Galveston, Texas 77555-1048, USA., 2006, Vol. 281(47), pp. 35598-35602
  118. He, T.C., Chan, T.A., Vogelstein, B. & Kinzler, K.W. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA., 1999, Vol. 99(3), pp. 335-345
  119. He, T.C., Sparks, A.B., Rago, C., Hermeking, H., Zawel, L., da Costa, L.T., Morin, P.J., Vogelstein, B. & Kinzler, K.W. Identification of c-MYC as a target of the APC pathway. Science, Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA., 1998, Vol. 281(5382), pp. 1509-1512
  120. Hecht, A. & Stemmler, M.P. Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4. J Biol Chem, Max-Planck-Institut für Immunbiologie, Stübeweg 51, D-79108 Freiburg, Germany. hecht@mm11.ukl.uni-freiburg.de, 2003, Vol. 278(6), pp. 3776-3785
  121. Heemers, H., Verrijdt, G., Organe, S., Claessens, F., Heyns, W., Verhoeven, G. & Swinnen, J.V. Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor. J Biol Chem, Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium., 2004, Vol. 279(29), pp. 30880-30887
  122. Heer, R. & Robson, C.N. Editorial comment on: delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate. Eur Urol, 2008, Vol. 54(6), pp. 1353
  123. Hegde, G.V., Munger, C.M., Emanuel, K., Joshi, A.D., Greiner, T.C., Weisenburger, D.D., Vose, J.M. & Joshi, S.S. Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma. Mol Cancer Ther, Department of Genetics, Cell Biology, and Anatomy, Center for Research in Leukemia and Lymphoma, University of Nebraska Medical Center, Omaha, NE 68198-6395, USA., 2008, Vol. 7(6), pp. 1450-1460
  124. Hendrix, N.D., Wu, R., Kuick, R., Schwartz, D.R., Fearon, E.R. & Cho, K.R. Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res, Department of Pathology, University of Michigan Medical School, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA., 2006, Vol. 66(3), pp. 1354-1362
  125. Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T., Masuyama, N. & Gotoh, Y. The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., 2004, Vol. 131(12), pp. 2791-2801
  126. Hlubek, F., Jung, A., Kotzor, N., Kirchner, T. & Brabletz, T. Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin. Cancer Res, Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany., 2001, Vol. 61(22), pp. 8089-8093
  127. Hlubek, F., Pfeiffer, S., Budczies, J., Spaderna, S., Jung, A., Kirchner, T. & Brabletz, T. Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. Br J Cancer, Department of Pathology, Ludwig-Maximilians University of Munich, Thalkirchner Str. 36, 80337 Munich, Germany. Falk.Hlubek@med.uni-muenchen.de, 2006, Vol. 94(11), pp. 1672-1677
  128. Horii, K., Suzuki, Y., Kondo, Y., Akimoto, M., Nishimura, T., Yamabe, Y., Sakaue, M., Sano, T., Kitagawa, T., Himeno, S., Imura, N. & Hara, S. Androgen-dependent gene expression of prostate-specific antigen is enhanced synergistically by hypoxia in human prostate cancer cells. Mol Cancer Res, Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Japan., 2007, Vol. 5(4), pp. 383-391
  129. Hossain, A. & Saunders, G.F. Synergistic cooperation between the beta-catenin signaling pathway and steroidogenic factor 1 in the activation of the Mullerian inhibiting substance type II receptor. J Biol Chem, Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030., 2003, Vol. 278(29), pp. 26511-26516
  130. Hovanes, K., Li, T.W., Munguia, J.E., Truong, T., Milovanovic, T., Marsh, J.L., Holcombe, R.F. & Waterman, M.L. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet, Microbiology and Molecular Genetics Department, University of California, Irvine, Irvine, California, USA., 2001, Vol. 28(1), pp. 53-57
  131. Howe, L.R., Subbaramaiah, K., Chung, W.J., Dannenberg, A.J. & Brown, A.M. Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Res, Strang Cancer Research Laboratory, The Rockefeller University, New York, New York 10021, USA., 1999, Vol. 59(7), pp. 1572-1577
  132. Howe, L.R., Watanabe, O., Leonard, J. & Brown, A.M.C. Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res, Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA. lrhowe@med.cornell.edu, 2003, Vol. 63(8), pp. 1906-1913
  133. Hsi, L.C., Angerman-Stewart, J. & Eling, T.E. Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. Carcinogenesis, National Institute of Environmental Health Sciences, Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, PO Box 12233, Research Triangle Park, NC 27709, USA., 1999, Vol. 20(11), pp. 2045-2049
  134. Hu, M.C., Mo, R., Bhella, S., Wilson, C.W., Chuang, P.-T., Hui, C.-C. & Rosenblum, N.D. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development, Program in Developmental Biology, Hospital for Sick Children, University of Toronto, Canada., 2006, Vol. 133(3), pp. 569-578
  135. Hu, M.C. & Rosenblum, N.D. Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development, Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada., 2005, Vol. 132(1), pp. 215-225
  136. Huang, M., Wang, Y., Sun, D., Zhu, H., Yin, Y., Zhang, W., Yang, S., Quan, L., Bai, J., Wang, S., Chen, Q., Li, S. & Xu, N. Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis. BMC Cancer, Center of Bioinformatics, National Laboratory of Genetic Engineering and Protein Engineering, College of Life Sciences, Peking University, Beijing, PR China. huangml@mail.cbi.pku.edu.cn, 2006, Vol. 6, pp. 221
  137. Huang, Z., Xie, H., Ioannidis, V., Held, W., Clevers, H., Sadim, M.S. & Sun, Z. Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway. J Immunol, Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA., 2006, Vol. 176(8), pp. 4880-4887
  138. Hubmann, R., Schwarzmeier, J.D., Shehata, M., Hilgarth, M., Duechler, M., Dettke, M. & Berger, R. Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia. Blood, Department of Hematology, Clinic of Internal Medicine I, University of Vienna, Vienna, Austria., 2002, Vol. 99(10), pp. 3742-3747
  139. Hussein, S.M., Duff, E.K. & Sirard, C. Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2. J Biol Chem, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada., 2003, Vol. 278(49), pp. 48805-48814
  140. Hynes, M., Stone, D.M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. & Rosenthal, A. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron, Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080, USA., 1997, Vol. 19(1), pp. 15-26
  141. Hynes, M., Ye, W., Wang, K., Stone, D., Murone, M., Sauvage, F. & Rosenthal, A. The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. Nat Neurosci, Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080, USA. mah@gene.com, 2000, Vol. 3(1), pp. 41-46
  142. Höflinger, S., Kesavan, K., Fuxa, M., Hutter, C., Heavey, B., Radtke, F. & Busslinger, M. Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J Immunol, Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria., 2004, Vol. 173(6), pp. 3935-3944
  143. Ikram, M.S., Neill, G.W., Regl, G., Eichberger, T., Frischauf, A.-M., Aberger, F., Quinn, A. & Philpott, M. GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol, Dentistry, University of London, UK. m.s.ikram@qmul.ac.uk, 2004, Vol. 122(6), pp. 1503-1509
  144. Im, J., Kim, H., Kim, S. & Jho, E.-H. Wnt/beta-catenin signaling regulates expression of PRDC, an antagonist of the BMP-4 signaling pathway. Biochem Biophys Res Commun, Department of Life Science, The University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul 130-743, Korea., 2007, Vol. 354(1), pp. 296-301
  145. Ingram, W.J., McCue, K.I., Tran, T.H., Hallahan, A.R. & Wainwright, B.J. Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., 2008, Vol. 27(10), pp. 1489-1500
  146. Ingram, W.J., Wicking, C.A., Grimmond, S.M., Forrest, A.R. & Wainwright, B.J. Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene, Institute for Molecular Bioscience and Department of Biochemistry and Molecular Biology, The University of Queensland, Queensland 4072, Australia., 2002, Vol. 21(53), pp. 8196-8205
  147. Ishiguro, H., Furukawa, Y., Daigo, Y., Miyoshi, Y., Nagasawa, Y., Nishiwaki, T., Kawasoe, T., Fujita, M., Satoh, S., Miwa, N., Fujii, Y. & Nakamura, Y. Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway. Jpn J Cancer Res, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan., 2000, Vol. 91(6), pp. 597-603
  148. Iso, T., Chung, G., Hamamori, Y. & Kedes, L. HERP1 is a cell type-specific primary target of Notch. J Biol Chem, Institute for Genetic Medicine, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA., 2002, Vol. 277(8), pp. 6598-6607
  149. Iso, T., Sartorelli, V., Chung, G., Shichinohe, T., Kedes, L. & Hamamori, Y. HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol, Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089-9075, USA., 2001, Vol. 21(17), pp. 6071-6079
  150. Iso, T., Sartorelli, V., Poizat, C., Iezzi, S., Wu, H.Y., Chung, G., Kedes, L. & Hamamori, Y. HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol, Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089-9075, USA., 2001, Vol. 21(17), pp. 6080-6089
  151. Itoh, F., Itoh, S., Goumans, M.-J., Valdimarsdottir, G., Iso, T., Dotto, G.P., Hamamori, Y., Kedes, L., Kato, M. & ten Dijke Pt, P. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J, Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam., 2004, Vol. 23(3), pp. 541-551
  152. Izumi, M., Yokoi, M., Nishikawa, N.S., Miyazawa, H., Sugino, A., Yamagishi, M., Yamaguchi, M., Matsukage, A., Yatagai, F. & Hanaoka, F. Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1. Biochim Biophys Acta, Division of Radioisotope Technology, RIKEN (The Institute of Physical and CHemical Research), Saitama, Japan. mizumi@postman.riken.go.jp, 2000, Vol. 1492(2-3), pp. 341-352
  153. Jansson, E.A., Are, A., Greicius, G., Kuo, I.-C., Kelly, D., Arulampalam, V. & Pettersson, S. The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. Proc Natl Acad Sci U S A, Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden., 2005, Vol. 102(5), pp. 1460-1465
  154. Jariwala, U., Prescott, J., Jia, L., Barski, A., Pregizer, S., Cogan, J.P., Arasheben, A., Tilley, W.D., Scher, H.I., Gerald, W.L., Buchanan, G., Coetzee, G.A. & Frenkel, B. Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA. jariwala@usc.edu, 2007, Vol. 6, pp. 39
  155. Jarriault, S., Bail, O.L., Hirsinger, E., Pourquié, O., Logeat, F., Strong, C.F., Brou, C., Seidah, N.G. & l, A.I. Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol, Unité de Biologie Moléculaire de l'Expression Génique, URA 1773 CNRS, Institut Pasteur, 75724 Paris Cedex 15, France., 1998, Vol. 18(12), pp. 7423-7431
  156. Jarriault, S., Brou, C., Logeat, F., Schroeter, E.H., Kopan, R. & Israel, A. Signalling downstream of activated mammalian Notch. Nature, Unité de Biologie Moléculaire de L'Expression Génique, URA 1149 CNRS, Institut Pasteur, Paris, France., 1995, Vol. 377(6547), pp. 355-358
  157. Jeanteur, P. [The role of APC in colonic cancerogenesis: zeroing in on Myc] Bull Cancer, Institut de génétique moléculaire de Montpellier., 1998, Vol. 85(11), pp. 925-928
  158. Jemtland, R., Divieti, P., Lee, K. & Segre, G.V. Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion. Bone, Endocrine Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA., 2003, Vol. 32(6), pp. 611-620
  159. hoon Jho, E., Zhang, T., Domon, C., Joo, C.-K., Freund, J.-N. & Costantini, F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol, Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA., 2002, Vol. 22(4), pp. 1172-1183
  160. Jorgensen, J.S. & Nilson, J.H. AR suppresses transcription of the LHbeta subunit by interacting with steroidogenic factor-1. Mol Endocrinol, Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106-4965, USA., 2001, Vol. 15(9), pp. 1505-1516
  161. Jung, H.-C. & Kim, K. Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis. Life Sci, College of Pharmacy, Chonnam National University, Gwangju, Korea., 2005, Vol. 77(11), pp. 1249-1262
  162. Kaga, S., Zhan, L., Altaf, E. & Maulik, N. Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium. J Mol Cell Cardiol, Molecular Cardiology Laboratory, Department of Surgery, University of Connecticut Health Center, 263, Farmington Avenue, Farmington, CT 06030-1110, USA., 2006, Vol. 40(1), pp. 138-147
  163. Kageyama, R. & Ohtsuka, T. The Notch-Hes pathway in mammalian neural development. Cell Res, Institute for Virus Research, Kyoto University, Japan. rkageyam@virus.kyoto-u.ac.jp, 1999, Vol. 9(3), pp. 179-188
  164. Kamei, J., Toyofuku, T. & Hori, M. Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation. Biochem Biophys Res Commun, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan., 2003, Vol. 312(2), pp. 380-387
  165. Kato, M., Seki, N., Sugano, S., Hashimoto, K., Masuho, Y., Muramatsu, M., Kaibuchi, K. & Nakafuku, M. Identification of sonic hedgehog-responsive genes using cDNA microarray. Biochem Biophys Res Commun, ra 630-01, Japan., 2001, Vol. 289(2), pp. 472-478
  166. Kato, T., Satoh, S., Okabe, H., Kitahara, O., Ono, K., Kihara, C., Tanaka, T., Tsunoda, T., Yamaoka, Y., Nakamura, Y. & Furukawa, Y. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. Neoplasia, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., 2001, Vol. 3(1), pp. 4-9
  167. Kawasoe, T., Furukawa, Y., Daigo, Y., Nishiwaki, T., Ishiguro, H., Fujita, M., Satoh, S., Miwa, N., Nagasawa, Y., Miyoshi, Y., Ogawa, M. & Nakamura, Y. Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin. Cancer Res, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan., 2000, Vol. 60(13), pp. 3354-3358
  168. Kennell, J.A., O'Leary, E.E., Gummow, B.M., Hammer, G.D. & MacDougald, O.A. T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol Cell Biol, Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E. Catherine Road, Ann Arbor, MI 48109-0622, USA., 2003, Vol. 23(15), pp. 5366-5375
  169. Kenny, P.A., Enver, T. & Ashworth, A. Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. BMC Cancer, Section of Gene Function and Regulation, Institute of Cancer Research, London, SW3 6JB, UK. pakenny@lbl.gov, 2005, Vol. 5, pp. 3
  170. Kim, P.J., Plescia, J., Clevers, H., Fearon, E.R. & Altieri, D.C. Survivin and molecular pathogenesis of colorectal cancer. Lancet, Department of Cancer Biology and the Cancer Center, University of Massachusetts, Medical School, Worcester, MA, USA., 2003, Vol. 362(9379), pp. 205-209
  171. Kim, T.H., Xiong, H., Zhang, Z. & Ren, B. beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. Oncogene, Laboratory of Gene Regulation, Ludwig Institute for Cancer Research, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA., 2005, Vol. 24(4), pp. 597-604
  172. Kim, W.B., Lewis, C.J., McCall, K.D., Malgor, R., Kohn, A.D., Moon, R.T. & Kohn, L.D. Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms. J Endocrinol, Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA., 2007, Vol. 193(1), pp. 93-106
  173. Kipp, A., Banning, A. & Brigelius-Flohé, R. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. Biol Chem, Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany., 2007, Vol. 388(10), pp. 1027-1033
  174. Koh, T.J., Bulitta, C.J., Fleming, J.V., Dockray, G.J., Varro, A. & Wang, T.C. Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., 2000, Vol. 106(4), pp. 533-539
  175. Kolligs, F.T., Nieman, M.T., Winer, I., Hu, G., Mater, D.V., Feng, Y., Smith, I.M., Wu, R., Zhai, Y., Cho, K.R. & Fearon, E.R. ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell, Department of Internal Medicine, Division of Medical Genetics and the Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., 2002, Vol. 1(2), pp. 145-155
  176. Kolly, C., Zakher, A., Strauss, C., Suter, M.M. & Müller, E.J. Keratinocyte transcriptional regulation of the human c-Myc promoter occurs via a novel Lef/Tcf binding element distinct from neoplastic cells. FEBS Lett, Molecular Dermatology, Institute of Animal Pathology, Vetsuisse Faculty, 3012 Bern, Switzerland., 2007, Vol. 581(10), pp. 1969-1976
  177. Komada, M., Saitsu, H., Shiota, K. & Ishibashi, M. Expression of Fgf15 is regulated by both activator and repressor forms of Gli2 in vitro. Biochem Biophys Res Commun, Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan., 2008, Vol. 369(2), pp. 350-356
  178. Koochekpour, S., Lee, T.-J., Wang, R., Sun, Y., Delorme, N., Hiraiwa, M., Grabowski, G.A., Culig, Z. & Minokadeh, A. Prosaposin is a novel androgen-regulated gene in prostate cancer cell line LNCaP. J Cell Biochem, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. skooch@lsuhsc.edu, 2007, Vol. 101(3), pp. 631-641
  179. Krebs, L.T., Deftos, M.L., Bevan, M.J. & Gridley, T. The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev Biol, The Jackson Laboratory, Bar Harbor, Maine 04609-1500, USA., 2001, Vol. 238(1), pp. 110-119
  180. Kumano, K., Chiba, S., Shimizu, K., Yamagata, T., Hosoya, N., Saito, T., Takahashi, T., Hamada, Y. & Hirai, H. Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. Blood, Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., 2001, Vol. 98(12), pp. 3283-3289
  181. Kump, E., Ji, J., Wernli, M., Häusermann, P. & Erb, P. Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis. Oncogene, Department of Biomedicine, Institute for Medical Microbiology, University of Basel, Petersplatz, Basel, Switzerland., 2008, Vol. 27(27), pp. 3856-3864
  182. Kuroda, K., Tani, S., Tamura, K., Minoguchi, S., Kurooka, H. & Honjo, T. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J Biol Chem, Department of Medical Chemistry, Kyoto University Faculty of Medicine, Yoshida Sakyo-ku, Kyoto 606-8501, Japan., 1999, Vol. 274(11), pp. 7238-7244
  183. Lapham, A., Adams, J.E., Paterson, A., Lee, M., Brimmell, M. & Packham, G. The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells. Gene, Cancer Research UK Clinical Centre, Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK., 2009, Vol. 432(1-2), pp. 112-117
  184. Laws, A.M. & Osborne, B.A. p53 regulates thymic Notch1 activation. Eur J Immunol, Department of Molecular and Cellular Biology, University of Massachusetts, Amherst 01003, USA., 2004, Vol. 34(3), pp. 726-734
  185. Lee, H.-S., Lee, D.C., Park, M.-H., Yang, S.-J., Lee, J.J., Kim, D.M., Jang, Y., Lee, J.-H., Choi, J.Y., Kang, Y.K., Kim, D.I., Park, K.C., Kim, S.-Y., Yoo, H.-S., Choi, E.-J. & Yeom, Y.I. STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells. Biochem Biophys Res Commun, nomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600, Republic of Korea., 2006, Vol. 345(3), pp. 1059-1067
  186. Lee, H.-S., Park, M.-H., Yang, S.-J., Park, K.C., Kim, N.-S., Kim, Y.-S., Kim, D.I., Yoo, H.-S., Choi, E.-J. & Yeom, Y.I. Novel candidate targets of Wnt/beta-catenin signaling in hepatoma cells. Life Sci, Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600, South Korea., 2007, Vol. 80(7), pp. 690-698
  187. Lee, S.-W., Moskowitz, M.A. & Sims, J.R. Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med, Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., 2007, Vol. 19(3), pp. 445-451
  188. Lei, Q., Jeong, Y., Misra, K., Li, S., Zelman, A.K., Epstein, D.J. & Matise, M.P. Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev Cell, Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, 08854, USA., 2006, Vol. 11(3), pp. 325-337
  189. Lei, S., Dubeykovskiy, A., Chakladar, A., Wojtukiewicz, L. & Wang, T.C. The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways. J Biol Chem, Division of Gastroenterology, Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York 10032, USA., 2004, Vol. 279(41), pp. 42492-42502
  190. Leung, J.Y., Kolligs, F.T., Wu, R., Zhai, Y., Kuick, R., Hanash, S., Cho, K.R. & Fearon, E.R. Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. J Biol Chem, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0638, USA., 2002, Vol. 277(24), pp. 21657-21665
  191. Li, C.-M., Kim, C.E., Margolin, A.A., Guo, M., Zhu, J., Mason, J.M., Hensle, T.W., Murty, V.V.V.S., Grundy, P.E., Fearon, E.R., D'Agati, V., Licht, J.D. & Tycko, B. CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. Am J Pathol, Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York, USA., 2004, Vol. 165(6), pp. 1943-1953
  192. Li, H., Ray, G., Yoo, B.H., Erdogan, M. & Rosen, K.V. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. J Biol Chem, Department of Pediatrics, Atlantic Research Centre, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada., 2009, Vol. 284(4), pp. 2012-2022
  193. Li, Q., Dashwood, W.M., Zhong, X., Nakagama, H. & Dashwood, R.H. Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Oncogene, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA., 2007, Vol. 26(42), pp. 6194-6202
  194. Li, X., Deng, W., Nail, C.D., Bailey, S.K., Kraus, M.H., Ruppert, J.M. & Lobo-Ruppert, S.M. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene, Department of Cell Biology, University of Alabama at Birmingham, 35294-3300, USA., 2006, Vol. 25(4), pp. 609-621
  195. Lickert, H., Domon, C., Huls, G., Wehrle, C., Duluc, I., Clevers, H., Meyer, B.I., Freund, J.N. & Kemler, R. Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development, Department of Molecular Embryology, Max-Planck Institute of Immunobiology, Stübeweg 51, D-79108 Freiburg, Germany., 2000, Vol. 127(17), pp. 3805-3813
  196. Liebig, B., Brabletz, T., Staege, M.S., Wulfänger, J., Riemann, D., Burdach, S. & Ballhausen, W.G. Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett, Department of Internal Medicine 1, Section Molecular GI Oncology, University of Halle-Wittenberg, Halle, Germany., 2005, Vol. 223(1), pp. 159-167
  197. Lipinski, R.J., Cook, C.H., Barnett, D.H., Gipp, J.J., Peterson, R.E. & Bushman, W. Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn, Division of Urology, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA., 2005, Vol. 233(3), pp. 829-836
  198. Liu, J.-J., Huang, B.H., Zhang, J., Carson, D.D. & Hooi, S.C. Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. J Cell Physiol, Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore., 2006, Vol. 207(2), pp. 287-292
  199. Liu, Y., Borchert, G.L., Surazynski, A. & Phang, J.M. Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. Oncogene, 1Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA., 2008, Vol. 27(53), pp. 6729-6737
  200. Liu, Z.-J., Xiao, M., Balint, K., Smalley, K.S.M., Brafford, P., Qiu, R., Pinnix, C.C., Li, X. & Herlyn, M. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA., 2006, Vol. 66(8), pp. 4182-4190
  201. Lleó, A., Berezovska, O., Ramdya, P., Fukumoto, H., Raju, S., Shah, T. & Hyman, B.T. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. J Biol Chem, Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02114, USA., 2003, Vol. 278(48), pp. 47370-47375
  202. Loeppen, S., Koehle, C., Buchmann, A. & Schwarz, M. A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. Carcinogenesis, Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tuebingen, Wilhelmstrasse 56, 72074 Tuebingen, Germany., 2005, Vol. 26(1), pp. 239-248
  203. Logan, C.Y. & Nusse, R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol, Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. cylogan@cmgm.stanford.edu, 2004, Vol. 20, pp. 781-810
  204. Longo, K.A., Kennell, J.A., Ochocinska, M.J., Ross, S.E., Wright, W.S. & MacDougald, O.A. Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem, Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622, USA., 2002, Vol. 277(41), pp. 38239-38244
  205. Louro, I.D., Bailey, E.C., Li, X., South, L.S., McKie-Bell, P.R., Yoder, B.K., Huang, C.C., Johnson, M.R., Hill, A.E., Johnson, R.L. & Ruppert, J.M. Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation. Cancer Res, Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, 35294, USA., 2002, Vol. 62(20), pp. 5867-5873
  206. Lu, Q.R., Yuk, D., Alberta, J.A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A.P., Stiles, C.D. & Rowitch, D.H. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., 2000, Vol. 25(2), pp. 317-329
  207. Luo, J., Ju, M.J. & Redies, C. Regionalized cadherin-7 expression by radial glia is regulated by Shh and Pax7 during chicken spinal cord development. Neuroscience, Institute of Anatomy I, Friedrich Schiller University, Teichgraben 7, D-07740 Jena, Germany. tluo@mti.uni-jena.de, 2006, Vol. 142(4), pp. 1133-1143
  208. Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P.M., Birchmeier, W. & Behrens, J. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol, Max Delbrueck Center for Molecular Medicine, D-13092 Berlin, Germany., 2002, Vol. 22(4), pp. 1184-1193
  209. Lévy, L., Neuveut, C., Renard, C.-A., Charneau, P., Branchereau, S., Gauthier, F., Nhieu, J.T.V., Cherqui, D., Petit-Bertron, A.-F., Mathieu, D. & Buendia, M.A. Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem, Unité de Recombinaison et Expression Génétique (Inserm U163), Département de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris, France., 2002, Vol. 277(44), pp. 42386-42393
  210. Löfstedt, T., Jögi, A., Sigvardsson, M., Gradin, K., Poellinger, L., Påhlman, S. & Axelson, H. Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. J Biol Chem, Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, S-205 02 Malmö, Sweden., 2004, Vol. 279(38), pp. 39223-39231
  211. Ma, Q., Sommer, L., Cserjesi, P. & Anderson, D.J. Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands. J Neurosci, Division of Biology 216-76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA., 1997, Vol. 17(10), pp. 3644-3652
  212. Machka, C., Kersten, M., Zobawa, M., Harder, A., Horsch, M., Halder, T., Lottspeich, F., de Angelis, M.H. & Beckers, J. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns, Institute of Experimental Genetics, GSF-National Research Center, Ingolstädter Landstr.1, 85764 Neuherberg, Germany., 2005, Vol. 6(1), pp. 94-101
  213. Magee, J.A., wei Chang, L., Stormo, G.D. & Milbrandt, J. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology, Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA., 2006, Vol. 147(1), pp. 590-598
  214. Maier, M.M. & Gessler, M. Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Biochem Biophys Res Commun, Physiologische Chemie I, Biozentrum der Universität Würzburg, Am Hubland, Würzburg, 97074, Germany., 2000, Vol. 275(2), pp. 652-660
  215. Makkonen, H., Kauhanen, M., Paakinaho, V., Jääskeläinen, T. & Palvimo, J.J. Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers. Nucleic Acids Res, Institute of Biomedicine/Medical Biochemistry, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland., 2009, Vol. 37(12), pp. 4135-4148
  216. Mankertz, J., Hillenbrand, B., Tavalali, S., Huber, O., Fromm, M. & Schulzke, J.D. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun, Department of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany. joachim.mankertz@medizin.fu-berlin.de, 2004, Vol. 314(4), pp. 1001-1007
  217. Mann, B., Gelos, M., Siedow, A., Hanski, M.L., Gratchev, A., Ilyas, M., Bodmer, W.F., Moyer, M.P., Riecken, E.O., Buhr, H.J. & Hanski, C. Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A, Department of Surgery, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, 12200 Berlin, Germany. mann@ukbf.fu-berlin.de, 1999, Vol. 96(4), pp. 1603-1608
  218. Marchenko, G.N., Marchenko, N.D., Leng, J. & Strongin, A.Y. Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. Biochem J, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, U.S.A., 2002, Vol. 363(Pt 2), pp. 253-262
  219. Marchenko, N.D., Marchenko, G.N., Weinreb, R.N., Lindsey, J.D., Kyshtoobayeva, A., Crawford, H.C. & Strongin, A.Y. Beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells. Int J Biochem Cell Biol, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92093, USA., 2004, Vol. 36(5), pp. 942-956
  220. Margiotti, K., Wafa, L.A., Cheng, H., Novelli, G., Nelson, C.C. & Rennie, P.S. Androgen-regulated genes differentially modulated by the androgen receptor coactivator L-dopa decarboxylase in human prostate cancer cells. Mol Cancer, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. katia.margiotti@vch.ca, 2007, Vol. 6, pp. 38
  221. Marigo, V., Johnson, R.L., Vortkamp, A. & Tabin, C.J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., 1996, Vol. 180(1), pp. 273-283
  222. Marker, A.J., Colosia, A.D., Tauler, A., Solomon, D.H., Cayre, Y., Lange, A.J., el Maghrabi, M.R. & Pilkis, S.J. Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression. J Biol Chem, Department of Physiology and Biophysics, State University of New York, Stony Brook 11794., 1989, Vol. 264(12), pp. 7000-7004
  223. Masckauchán, T.N.H., Shawber, C.J., Funahashi, Y., Li, C.-M. & Kitajewski, J. Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis, Department of OB/GYN, Columbia University Medical Center, New York, NY 10032, USA., 2005, Vol. 8(1), pp. 43-51
  224. McGrew, L.L., Takemaru, K., Bates, R. & Moon, R.T. Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus. Mech Dev, Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, University of Washington School of Medicine, Seattle, WA 98195, USA., 1999, Vol. 87(1-2), pp. 21-32
  225. Meehan, K.L. & Sadar, M.D. Quantitative profiling of LNCaP prostate cancer cells using isotope-coded affinity tags and mass spectrometry. Proteomics, Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, BC, Canada., 2004, Vol. 4(4), pp. 1116-1134
  226. Mei, J.M., Hord, N.G., Winterstein, D.F., Donald, S.P. & Phang, J.M. Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc. Carcinogenesis, Laboratory of Nutritional and Molecular Regulation, Division of Basic Sciences, National Cancer Institute, Frederick, MD 21702, USA., 1999, Vol. 20(4), pp. 737-740
  227. Mestdagt, M., Polette, M., Buttice, G., Noël, A., Ueda, A., Foidart, J.-M. & Gilles, C. Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells. Int J Cancer, Laboratory of Developmental and Tumour Biology, University of Liège, Liège, Belgium., 2006, Vol. 118(1), pp. 35-42
  228. Minter, L.M., Turley, D.M., Das, P., Shin, H.M., Joshi, I., Lawlor, R.G., Cho, O.H., Palaga, T., Gottipati, S., Telfer, J.C., Kostura, L., Fauq, A.H., Simpson, K., Such, K.A., Miele, L., Golde, T.E., Miller, S.D. & Osborne, B.A. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol, Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, 01003, USA., 2005, Vol. 6(7), pp. 680-688
  229. Morimura, T., Miyatani, S., Kitamura, D. & Goitsuka, R. Notch signaling suppresses IgH gene expression in chicken B cells: implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius. J Immunol, Division of Molecular Biology, Research Institute for Biological Sciences, Science University of Tokyo, Chiba, Japan., 2001, Vol. 166(5), pp. 3277-3283
  230. Morrow, D., Scheller, A., Birney, Y.A., Sweeney, C., Guha, S., Cummins, P.M., Murphy, R., Walls, D., Redmond, E.M. & Cahill, P.A. Notch-mediated CBF-1/RBP-Jkappa-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am J Physiol Cell Physiol, Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland., 2005, Vol. 289(5), pp. C1188-C1196
  231. Murtha, P., Tindall, D.J. & Young, C.Y. Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5' promoter region of the gene. Biochemistry, Department of Urology, Mayo Clinic/Foundation, Rochester, Minnesota 55905., 1993, Vol. 32(25), pp. 6459-6464
  232. Nakagawa, O., McFadden, D.G., Nakagawa, M., Yanagisawa, H., Hu, T., Srivastava, D. & Olson, E.N. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A, Departments of Molecular Biology and Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA., 2000, Vol. 97(25), pp. 13655-13660
  233. Nakazawa, M., Ishii, H., Nakamura, H., Yoshino, S.I., Fukamizu, A., Nishioka, K. & Nakajima, T. NFkappaB2 (p52) promoter activation via Notch signaling pathway in rheumatoid synoviocytes. Int J Mol Med, Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St. Marianna University, School of Medicine, Kanagawa 216-8512, Japan., 2001, Vol. 7(1), pp. 31-35
  234. Nefedova, Y., Cheng, P., Alsina, M., Dalton, W.S. & Gabrilovich, D.I. Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA., 2004, Vol. 103(9), pp. 3503-3510
  235. Nelson, P.S., Gan, L., Ferguson, C., Moss, P., Gelinas, R., Hood, L. & Wang, K. Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. Proc Natl Acad Sci U S A, Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA. psnels@u.washington.edu, 1999, Vol. 96(6), pp. 3114-3119
  236. Nelson, R.W. & Gumbiner, B.M. A cell-free assay system for beta-catenin signaling that recapitulates direct inductive events in the early xenopus laevis embryo. J Cell Biol, Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA., 1999, Vol. 147(2), pp. 367-374
  237. Nishihara, S., Tsuda, L. & Ogura, T. The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem Biophys Res Commun, Institute of Development, Aging and Cancer, Tohoku University, Aoba, Sendai, Miyagi, Japan., 2003, Vol. 311(1), pp. 55-63
  238. Norvell, S.M., Alvarez, M., Bidwell, J.P. & Pavalko, F.M. Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif Tissue Int, IN U Sch Med, Indianapolis, 2004, Vol. 75(5), pp. 396-404
  239. Noseda, M., Fu, Y., Niessen, K., Wong, F., Chang, L., McLean, G. & Karsan, A. Smooth Muscle alpha-actin is a direct target of Notch/CSL. Circ Res, Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, Canada., 2006, Vol. 98(12), pp. 1468-1470
  240. Oakley, F., Mann, J., Ruddell, R.G., Pickford, J., Weinmaster, G. & Mann, D.A. Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J Biol Chem, Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, United Kingdom., 2003, Vol. 278(27), pp. 24359-24370
  241. Ohlen, T.V. & Hooper, J.E. Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer. Mech Dev, Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA., 1997, Vol. 68(1-2), pp. 149-156
  242. Ohlen, T.V., Lessing, D., Nusse, R. & Hooper, J.E. Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci U S A, Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA., 1997, Vol. 94(6), pp. 2404-2409
  243. Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F. & Kageyama, R. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J, Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, USA., 1999, Vol. 18(8), pp. 2196-2207
  244. Okuyama, R., Nguyen, B.-C., Talora, C., Ogawa, E., di Vignano, A.T., Lioumi, M., Chiorino, G., Tagami, H., Woo, M. & Dotto, G.P. High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell, Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., 2004, Vol. 6(4), pp. 551-562
  245. Oswald, F., Liptay, S., Adler, G. & Schmid, R.M. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol, Department of Internal Medicine, University of Ulm, Germany., 1998, Vol. 18(4), pp. 2077-2088
  246. Ovejero, C., Cavard, C., Périanin, A., Hakvoort, T., Vermeulen, J., Godard, C., Fabre, M., Chafey, P., Suzuki, K., Romagnolo, B., Yamagoe, S. & Perret, C. Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver. Hepatology, Institut Cochin, Département GDPM, Paris, France., 2004, Vol. 40(1), pp. 167-176
  247. Pan, L., Glenn, S.T., Jones, C.A. & Gross, K.W. Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch. J Biol Chem, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263-0001, USA., 2005, Vol. 280(21), pp. 20860-20866
  248. Patel, N.S., Li, J.-L., Generali, D., Poulsom, R., Cranston, D.W. & Harris, A.L. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res, Molecular Oncology Laboratories, Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, London. United Kingdom., 2005, Vol. 65(19), pp. 8690-8697 article(Pendas-Franco2008) Pendás-Franco, N., García, J.M., Peña, C., Valle, N., Pálmer, H.G., Heinäniemi, M., Carlberg, C., Jiménez, B., Bonilla, F., Muñoz, A. & González-Sancho, J.M. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. Oncogene, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain., 2008, Vol. 27(32), pp. 4467-4477
  249. Petropoulos, H., Gianakopoulos, P.J., Ridgeway, A.G. & Skerjanc, I.S. Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells. J Biol Chem, Department of Biochemistry, Medical Sciences Building, The University of Western Ontario, London, Ontario N6A 5C1, Canada., 2004, Vol. 279(23), pp. 23874-23881
  250. Pilon, N., Oh, K., Sylvestre, J.-R., Bouchard, N., Savory, J. & Lohnes, D. Cdx4 is a direct target of the canonical Wnt pathway. Dev Biol, Institut de Recherches Cliniques de Montréal, Québec, Canada., 2006, Vol. 289(1), pp. 55-63
  251. Pirot, P., van Grunsven, L.A., Marine, J.-C., Huylebroeck, D. & Bellefroid, E.J. Direct regulation of the Nrarp gene promoter by the Notch signaling pathway. Biochem Biophys Res Commun, Laboratoire d'Embryologie Moléculaire, Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, rue des Profs. Jeener et Brachet 12, B-6041 Gosselies, Belgium., 2004, Vol. 322(2), pp. 526-534
  252. de la Pompa, J.L., Wakeham, A., Correia, K.M., Samper, E., Brown, S., Aguilera, R.J., Nakano, T., Honjo, T., Mak, T.W., Rossant, J. & Conlon, R.A. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development, Amgen Institute, Toronto, Ontario, Canada. Jose.delaPompa@amgen.com, 1997, Vol. 124(6), pp. 1139-1148
  253. Pon, Y.L. & Wong, A.S.T. Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 up-regulation via the beta-catenin/T-cell factor signaling pathway. Mol Endocrinol, Department of Zoology, University of Hong Kong, Pokfulam Road, Hong Kong., 2006, Vol. 20(12), pp. 3336-3350
  254. Prescott, J., Jariwala, U., Jia, L., Cogan, J.P., Barski, A., Pregizer, S., Shen, H.C., Arasheben, A., Neilson, J.J., Frenkel, B. & Coetzee, G.A. Androgen receptor-mediated repression of novel target genes. Prostate, Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., 2007, Vol. 67(13), pp. 1371-1383
  255. Proweller, A., Pear, W.S. & Parmacek, M.S. Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., 2005, Vol. 280(10), pp. 8994-9004
  256. Pu, Y., Huang, L. & Prins, G.S. Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Dev Biol, Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., 2004, Vol. 273(2), pp. 257-275
  257. Quinkler, M., Bujalska, I.J., Kaur, K., Onyimba, C.U., Buhner, S., Allolio, B., Hughes, S.V., Hewison, M. & Stewart, P.M. Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney. Hypertension, Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TT, UK., 2005, Vol. 46(4), pp. 787-798
  258. Rahmani, M., Read, J.T., Carthy, J.M., McDonald, P.C., Wong, B.W., Esfandiarei, M., Si, X., Luo, Z., Luo, H., Rennie, P.S. & McManus, B.M. Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells. J Biol Chem, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada., 2005, Vol. 280(13), pp. 13019-13028
  259. Regl, G., Kasper, M., Schnidar, H., Eichberger, T., Neill, G.W., Ikram, M.S., Quinn, A.G., Philpott, M.P., Frischauf, A.-M. & Aberger, F. The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Oncogene, Institute of Genetics, University of Salzburg, Hellbrunner Strasse 34, A-5020 Salzburg, Austria., 2004, Vol. 23(6), pp. 1263-1274
  260. Regl, G., Neill, G.W., Eichberger, T., Kasper, M., Ikram, M.S., Koller, J., Hintner, H., Quinn, A.G., Frischauf, A.-M. & Aberger, F. Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Oncogene, Institute of Genetics, University of Salzburg, A-5020 Salzburg, Austria., 2002, Vol. 21(36), pp. 5529-5539
  261. Reizis, B. & Leder, P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev, Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA., 2002, Vol. 16(3), pp. 295-300
  262. Renard, C.-A., Labalette, C., Armengol, C., Cougot, D., Wei, Y., Cairo, S., Pineau, P., Neuveut, C., de Reyniès, A., Dejean, A., Perret, C. & Buendia, M.-A. Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer. Cancer Res, Institut National de la Sante et de la Recherche Medicale U579, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France., 2007, Vol. 67(3), pp. 901-910
  263. Reya, T., Duncan, A.W., Ailles, L., Domen, J., Scherer, D.C., Willert, K., Hintz, L., Nusse, R. & Weissman, I.L. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. t.reya@duke.edu, 2003, Vol. 423(6938), pp. 409-414
  264. Rivat, C., Floch, N.L., Sabbah, M., Teyrol, I., Redeuilh, G., Bruyneel, E., Mareel, M., Matrisian, L.M., Crawford, H.C., Gespach, C. & Attoub, S. Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion. FASEB J, INSERM U 482, Hôpital Saint-Antoine, 75571, Paris Cedex 12, France., 2003, Vol. 17(12), pp. 1721-1723 article(Robert-Moreno2005) Robert-Moreno, A., Espinosa, L., de la Pompa, J.L. & Bigas, A. RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development, Centre Oncologia Molecular, IDIBELL-Institut de Recerca Oncologica, Hospitalet, Barcelona 08907, Spain., 2005, Vol. 132(5), pp. 1117-1126
  265. Rock, R., Heinrich, A.C., Schumacher, N. & Gessler, M. Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain. Dev Dyn, University of Wuerzburg, Theodor-Boveri-Institute (Biocenter), Physiological Chemistry I, Am Hubland, Wuerzburg, Germany., 2005, Vol. 234(3), pp. 602-612
  266. Rockman, S.P., Currie, S.A., Ciavarella, M., Vincan, E., Dow, C., Thomas, R.J. & Phillips, W.A. Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma. J Biol Chem, Surgical Oncology Research Laboratory, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia., 2001, Vol. 276(48), pp. 45113-45119
  267. Rodova, M., Islam, M.R., Maser, R.L. & Calvet, J.P. The polycystic kidney disease-1 promoter is a target of the beta-catenin/T-cell factor pathway. J Biol Chem, Department of Biochemistry and Molecular Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA., 2002, Vol. 277(33), pp. 29577-29583
  268. Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T. & Clevers, H. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science, Department of Immunology and Center for Biomedical Genetics, Department of Pathology, University Medical Center Utrecht, Post Office Box 85500, 3508 GA Utrecht, Netherlands., 1999, Vol. 285(5435), pp. 1923-1926
  269. Ross, S.E., Hemati, N., Longo, K.A., Bennett, C.N., Lucas, P.C., Erickson, R.L. & MacDougald, O.A. Inhibition of adipogenesis by Wnt signaling. Science, Department of Physiology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA., 2000, Vol. 289(5481), pp. 950-953
  270. Rother, K., Johne, C., Spiesbach, K., Haugwitz, U., Tschöp, K., Wasner, M., Klein-Hitpass, L., Möröy, T., Mössner, J. & Engeland, K. Identification of Tcf-4 as a transcriptional target of p53 signalling. Oncogene, Medizinische Klinik und Poliklinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, Leipzig D-04103, Germany., 2004, Vol. 23(19), pp. 3376-3384
  271. Roura, S., Martínez, D., Piedra, J., Miravet, S., de Herreros, A.G. & Duñach, M. APC 3 x 15 beta-catenin-binding domain potentiates beta-catenin association to TBP and upregulates TCF-4 transcriptional activity. Biochem Biophys Res Commun, Unitat de Biologia Cel.lular i Molecular, Institut Municipal d'Investigació Mèdica, Universitat Pompeu Fabra, 08003, Barcelona, Spain. sroura@hsp.santpau.es, 2003, Vol. 309(4), pp. 830-835
  272. Saegusa, M., Hashimura, M., Kuwata, T., Hamano, M. & Okayasu, I. Upregulation of TCF4 expression as a transcriptional target of beta-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells. Lab Invest, Department of Pathology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan. msaegusa@med.kitasato-u.ac.jp, 2005, Vol. 85(6), pp. 768-779
  273. Saegusa, M., Hashimura, M., Kuwata, T., Hamano, M. & Okayasu, I. Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells. Am J Pathol, Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan. msaegusa@med.kitasato-u.ac.jp, 2004, Vol. 164(5), pp. 1739-1749
  274. Saegusa, M., Hashimura, M., Kuwata, T., Hamano, M., Watanabe, J., Kawaguchi, M. & Okayasu, I. Transcription factor Egr1 acts as an upstream regulator of beta-catenin signalling through up-regulation of TCF4 and p300 expression during trans-differentiation of endometrial carcinoma cells. J Pathol, Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. msaegusa@med.kitasato-u.ac.jp, 2008, Vol. 216(4), pp. 521-532
  275. Saitsu, H., Komada, M., Suzuki, M., Nakayama, R., Motoyama, J., Shiota, K. & Ishibashi, M. Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev Dyn, Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan., 2005, Vol. 232(2), pp. 282-292
  276. Sakamoto, K., Yamaguchi, S., Ando, R., Miyawaki, A., Kabasawa, Y., Takagi, M., Li, C.L., Perbal, B. & ichi Katsube, K. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem, Department of Molecular Pathology, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan., 2002, Vol. 277(33), pp. 29399-29405
  277. Sarmento, L.M., Huang, H., Limon, A., Gordon, W., Fernandes, J., Tavares, M.J., Miele, L., Cardoso, A.A., Classon, M. & Carlesso, N. Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med, Center of Regenerative Medicine and Technology, Massachusetts General Hospital, Boston, MA, USA., 2005, Vol. 202(1), pp. 157-168
  278. Sasaki, H., Hui, C., Nakafuku, M. & Kondoh, H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development, Laboratory of Developmental Biology, Osaka University, Suita, Japan. hsasaki@imcb.osaka-u.ac.jp, 1997, Vol. 124(7), pp. 1313-1322
  279. Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. & Kondoh, H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development, Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565-0871, Japan. hsasaki@imcb.osaka-u.ac.jp, 1999, Vol. 126(17), pp. 3915-3924 article(Schmidt-Ott2007) Schmidt-Ott, K.M., Masckauchan, T.N.H., Chen, X., Hirsh, B.J., Sarkar, A., Yang, J., Paragas, N., Wallace, V.A., Dufort, D., Pavlidis, P., Jagla, B., Kitajewski, J. & Barasch, J. beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA. kms2115@columbia.edu, 2007, Vol. 134(17), pp. 3177-3190
  280. Schroeder, T., Kohlhof, H., Rieber, N. & Just, U. Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression. J Immunol, Institute of Clinical Molecular Biology and Tumor Genetics, GSF-National Research Center for Environment and Health, Munich, Germany., 2003, Vol. 170(11), pp. 5538-5548
  281. Schwartz, D.R., Wu, R., Kardia, S.L.R., Levin, A.M., Huang, C.-C., Shedden, K.A., Kuick, R., Misek, D.E., Hanash, S.M., Taylor, J.M.G., Reed, H., Hendrix, N., Zhai, Y., Fearon, E.R. & Cho, K.R. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res, Department of Pathology, College of Literature Science and the Arts, University of Michigan, Ann Arbor, Michigan 48109-0638, USA., 2003, Vol. 63(11), pp. 2913-2922
  282. Sekiya, T., Adachi, S., Kohu, K., Yamada, T., Higuchi, O., Furukawa, Y., Nakamura, Y., Nakamura, T., Tashiro, K., Kuhara, S., Ohwada, S. & Akiyama, T. Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem, , Japan., 2004, Vol. 279(8), pp. 6840-6846
  283. Shafer, S.L. & Towler, D.A. Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J Mol Cell Cardiol, Washington University School of Medicine, Center for Cardiovascular Research, Internal Medicine/BMD, Campus Box 8301, 660 South Euclid Ave, St. Louis, MO 63110, USA., 2009, Vol. 46(5), pp. 621-635
  284. Shawber, C.J., Das, I., Francisco, E. & Kitajewski, J. Notch signaling in primary endothelial cells. Ann N Y Acad Sci, Department of Pathology and OB/GYN, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA., 2003, Vol. 995, pp. 162-170
  285. Shekhar, M.P.V., Tait, L. & Gerard, B. Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. Mol Cancer Res, Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA. shekharm@karmanos.org, 2006, Vol. 4(10), pp. 729-745
  286. Shelton, D.N., Sandoval, I.T., Eisinger, A., Chidester, S., Ratnayake, A., Ireland, C.M. & Jones, D.A. Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA., 2006, Vol. 66(15), pp. 7571-7577
  287. Shen, Q. & Christakos, S. The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin. J Biol Chem, Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School and Graduate School for Biomedical Sciences, Newark, New Jersey 07103, USA., 2005, Vol. 280(49), pp. 40589-40598
  288. Shiels, A., Jeffery, S., Phillips, I.R., Shephard, E.A., Wilson, C.A. & Carter, N.D. Androgen-linked control of rat liver carbonic anhydrase III. Biosci Rep, 1983, Vol. 3(5), pp. 475-478
  289. Shih, A.H. & Holland, E.C. Notch signaling enhances nestin expression in gliomas. Neoplasia, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA., 2006, Vol. 8(12), pp. 1072-1082
  290. Shimokawa, T., Furukawa, Y., Sakai, M., Li, M., Miwa, N., Lin, Y.-M. & Nakamura, Y. Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex. Cancer Res, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., 2003, Vol. 63(19), pp. 6116-6120
  291. Shiou, S.-R., Singh, A.B., Moorthy, K., Datta, P.K., Washington, M.K., Beauchamp, R.D. & Dhawan, P. Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, Surgical Oncology Research Laboratories, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA., 2007, Vol. 67(4), pp. 1571-1579
  292. Shtutman, M., Zhurinsky, J., Oren, M., Levina, E. & Ben-Ze'ev, A. PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription. Cancer Res, Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel., 2002, Vol. 62(20), pp. 5947-5954
  293. Shu, W., Guttentag, S., Wang, Z., Andl, T., Ballard, P., Lu, M.M., Piccolo, S., Birchmeier, W., Whitsett, J.A., Millar, S.E. & Morrisey, E.E. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., 2005, Vol. 283(1), pp. 226-239
  294. Singh, R., Bhasin, S., Braga, M., Artaza, J.N., Pervin, S., Taylor, W.E., Krishnan, V., Sinha, S.K., Rajavashisth, T.B. & Jasuja, R. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology, Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA. rajansingh@mednet.ucla.edu, 2009, Vol. 150(3), pp. 1259-1268
  295. Smaele, E.D., Fragomeli, C., Ferretti, E., Pelloni, M., Po, A., Canettieri, G., Coni, S., Marcotullio, L.D., Greco, A., Moretti, M., Rocco, C.D., Pazzaglia, S., Maroder, M., Screpanti, I., Giannini, G. & Gulino, A. An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma. Neoplasia, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., 2008, Vol. 10(1), pp. 89-98
  296. Solecki, D.J., Gromeier, M., Mueller, S., Bernhardt, G. & Wimmer, E. Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. J Biol Chem, Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, 11794, USA. soleckd@mail.rockefeller.edu, 2002, Vol. 277(28), pp. 25697-25702
  297. Souazé, F., Viardot-Foucault, V., Roullet, N., Miou-Leong, M.T., Gompel, A., Bruyneel, E., Comperat, E., Faux, M.C., Mareel, M., Rostène, W., Fléjou, J.-F., Gespach, C. & Forgez, P. Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas. Carcinogenesis, INSERM U673-UPMC, Department of Pathology, 184 Rue Du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France., 2006, Vol. 27(4), pp. 708-716
  298. Spiegelman, V.S., Slaga, T.J., Pagano, M., Minamoto, T., Ronai, Z. & Fuchs, S.Y. Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell, AMC Cancer Research Center, Denver, Colorado 80214, USA., 2000, Vol. 5(5), pp. 877-882
  299. Spychala, J. & Kitajewski, J. Wnt and beta-catenin signaling target the expression of ecto-5'-nucleotidase and increase extracellular adenosine generation. Exp Cell Res, Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. jozek@med.unc.edu, 2004, Vol. 296(2), pp. 99-108
  300. Sriuranpong, V., Borges, M.W., Ravi, R.K., Arnold, D.R., Nelkin, B.D., Baylin, S.B. & Ball, D.W. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res, Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA., 2001, Vol. 61(7), pp. 3200-3205
  301. Stein, U., Arlt, F., Walther, W., Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W., Schlag, P.M. & Shoemaker, R.H. The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. Gastroenterology, Department of Surgery and Surgical Oncology, Robert-Rössle Cancer Hospital, Charité Campus Buch, Berlin, Germany. ustein@mdc-berlin.de, 2006, Vol. 131(5), pp. 1486-1500
  302. Stepan, V., Ramamoorthy, S., Nitsche, H., Zavros, Y., Merchant, J.L. & Todisco, A. Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA., 2005, Vol. 280(16), pp. 15700-15708
  303. Stone, C.D., Chen, Z.Y. & Tseng, C.C. Gut-enriched Krüppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. FEBS Lett, Section of Gastroenterology, Boston VA Medical Center and Boston University School of Medicine, EBRC X-513, 650 Albany Street, MA 02118, USA., 2002, Vol. 530(1-3), pp. 147-152
  304. Strobl, L.J., Höfelmayr, H., Marschall, G., Brielmeier, M., Bornkamm, G.W. & Zimber-Strobl, U. Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2. J Virol, GSF-National Research Center for Environment and Health, Institute for Clinical Molecular Biology and Tumor Genetics, D-81377 Munich, Germany., 2000, Vol. 74(4), pp. 1727-1735
  305. Surendran, K. & Simon, T.C. CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am J Physiol Renal Physiol, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA., 2003, Vol. 284(4), pp. F653-F662
  306. Swinnen, J.V., Esquenet, M., Rosseels, J., Claessens, F., Rombauts, W., Heyns, W. & Verhoeven, G. A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP. DNA Cell Biol, Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Belgium., 1996, Vol. 15(3), pp. 197-208
  307. Takahashi, M., Fujita, M., Furukawa, Y., Hamamoto, R., Shimokawa, T., Miwa, N., Ogawa, M. & Nakamura, Y. Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan., 2002, Vol. 62(20), pp. 5651-5656
  308. Takahashi, M., Nakamura, Y., Obama, K. & Furukawa, Y. Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. Int J Oncol, Laboratory of Molecular Medicine, The University of Tokyo, Minato-ku, Tokyo, Japan., 2005, Vol. 27(6), pp. 1483-1487
  309. Takahashi, M., Tsunoda, T., Seiki, M., Nakamura, Y. & Furukawa, Y. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan., 2002, Vol. 21(38), pp. 5861-5867
  310. Takayama, K., Kaneshiro, K., Tsutsumi, S., Horie-Inoue, K., Ikeda, K., Urano, T., Ijichi, N., Ouchi, Y., Shirahige, K., Aburatani, H. & Inoue, S. Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis. Oncogene, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., 2007, Vol. 26(30), pp. 4453-4463
  311. Takeda, K., Kinoshita, I., Shimizu, Y., Ohba, Y., Itoh, T., Matsuno, Y., Shichinohe, T. & Dosaka-Akita, H. Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. BMC Cancer, Department of Medical Oncology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan. kayoko-t@med.hokudai.ac.jp, 2008, Vol. 8, pp. 328
  312. Tanimizu, N. & Miyajima, A. Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci, Stem Cell Regulation, Kanagawa Academy of Science and Technology, Teikyo University Biotechnology Research Center, 907 Nogawa, Kawasaki, 216-0001, Japan., 2004, Vol. 117(Pt 15), pp. 3165-3174
  313. Tapia, J.C., Torres, V.A., Rodriguez, D.A., Leyton, L. & Quest, A.F.G. Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. Proc Natl Acad Sci U S A, Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 838-0453, Chile., 2006, Vol. 103(41), pp. 15079-15084
  314. Teh, M.-T., Wong, S.-T., Neill, G.W., Ghali, L.R., Philpott, M.P. & Quinn, A.G. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res, The London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, United Kingdom. m.t.teh@qmul.ac.uk, 2002, Vol. 62(16), pp. 4773-4780
  315. Tetsu, O. & McCormick, F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143-0128, USA., 1999, Vol. 398(6726), pp. 422-426
  316. Toni, E.N.D., Thieme, S.E., Herbst, A., Behrens, A., Stieber, P., Jung, A., Blum, H., Göke, B. & Kolligs, F.T. OPG is regulated by beta-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer. Clin Cancer Res, Department of Medicine II, University of Munich, Munich, Germany., 2008, Vol. 14(15), pp. 4713-4718
  317. Torisu, Y., Watanabe, A., Nonaka, A., Midorikawa, Y., Makuuchi, M., Shimamura, T., Sugimura, H., Niida, A., Akiyama, T., Iwanari, H., Kodama, T., Zeniya, M. & Aburatani, H. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. Cancer Sci, Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan., 2008, Vol. 99(6), pp. 1139-1146
  318. Valenta, T., Lukas, J. & Korinek, V. HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. Nucleic Acids Res, Institute of Molecular Genetics Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic., 2003, Vol. 31(9), pp. 2369-2380
  319. Vignjevic, D., Schoumacher, M., Gavert, N., Janssen, K.-P., Jih, G., Laé, M., Louvard, D., Ben-Ze'ev, A. & Robine, S. Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res, UMR 144 Centre National de la Recherche Scientifique and Department of Pathology, Institut Curie, 25 rue d'Ulm, 75248 Paris Cedex 05, France. danijela.vignjevic@curie.fr, 2007, Vol. 67(14), pp. 6844-6853
  320. Volpert, O.V., Pili, R., Sikder, H.A., Nelius, T., Zaichuk, T., Morris, C., Shiflett, C.B., Devlin, M.K., Conant, K. & Alani, R.M. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell, Department of Urology and RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA., 2002, Vol. 2(6), pp. 473-483
  321. Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M. & Tabin, C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., 1996, Vol. 273(5275), pp. 613-622
  322. Wang, C.D., Chang, G.D., Lee, Y.K. & Chen, H. A functional composite cis-element for NF kappa b and RBJ kappa in the rat pregnancy-specific glycoprotein gene. Biol Reprod, Taiwan Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan., 2001, Vol. 65(5), pp. 1437-1443
  323. Wang, H., Wen, S., Bunnett, N.W., Leduc, R., Hollenberg, M.D. & MacNaughton, W.K. Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. J Biol Chem, Inflammation Research Network, University of Calgary, Calgary, Alberta T2N 4N1, Canada., 2008, Vol. 283(2), pp. 809-815
  324. Wang, R., wu Zhang, Y., Sun, P., Liu, R., Zhang, X., Zhang, X., Xia, K., Xia, J., Xu, H. & Zhang, Z. Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol Cell Biol, National Laboratory of Medical Genetics of China, Xiang-Ya Hospital, Central South University, 410078 Changsha, Hunan, China., 2006, Vol. 26(4), pp. 1347-1354
  325. Wang, R., Zhang, Y.-W., Zhang, X., Liu, R., Zhang, X., Hong, S., Xia, K., Xia, J., Zhang, Z. & Xu, H. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J, Laboratory of Molecular and Cellular Neuroscience, School of Life Sciences, Xiamen University, Xiamen, China., 2006, Vol. 20(8), pp. 1275-1277
  326. Wang, W., Campos, A.H., Prince, C.Z., Mou, Y. & Pollman, M.J. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. J Biol Chem, Cardiovascular Research Institute, Morehouse School of Medicine, Research Wing, Atlanta, Georgia 30310, USA., 2002, Vol. 277(26), pp. 23165-23171
  327. Weng, A.P., Millholland, J.M., Yashiro-Ohtani, Y., Arcangeli, M.L., Lau, A., Wai, C., Bianco, C.D., Rodriguez, C.G., Sai, H., Tobias, J., Li, Y., Wolfe, M.S., Shachaf, C., Felsher, D., Blacklow, S.C., Pear, W.S. & Aster, J.C. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., 2006, Vol. 20(15), pp. 2096-2109
  328. Werth, M., Gebhardt, R. & Gaunitz, F. Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors. Hepatology, Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Leipzig, Germany., 2006, Vol. 44(4), pp. 967-975
  329. White, P.H., Farkas, D.R. & Chapman, D.L. Regulation of Tbx6 expression by Notch signaling. Genesis, Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., 2005, Vol. 42(2), pp. 61-70
  330. Wielenga, V.J., Smits, R., Korinek, V., Smit, L., Kielman, M., Fodde, R., Clevers, H. & Pals, S.T. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol, Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands., 1999, Vol. 154(2), pp. 515-523
  331. Willert, J., Epping, M., Pollack, J.R., Brown, P.O. & Nusse, R. A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 USA. jennifer.willert@cox.net, 2002, Vol. 2, pp. 8
  332. Wu, B., Crampton, S.P. & Hughes, C.C.W. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity, Center for Immunology, Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA., 2007, Vol. 26(2), pp. 227-239
  333. Xie, H., Huang, Z., Sadim, M.S. & Sun, Z. Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL. J Immunol, Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA., 2005, Vol. 175(12), pp. 7981-7988
  334. Xie, W., Jin, L., Mei, Y. & Wu, M. E2F1 represses beta-catenin/TCF activity by direct upregulation of Siah1. J Cell Mol Med, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China., 2008
  335. Xu, J., Srinivas, B.P., Tay, S.Y., Mak, A., Yu, X., Lee, S.G.P., Yang, H., Govindarajan, K.R., Leong, B., Bourque, G., Mathavan, S. & Roy, S. Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development. Genetics, re., 2006, Vol. 174(2), pp. 735-752
  336. Xu, L., Corcoran, R.B., Welsh, J.W., Pennica, D. & Levine, A.J. WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA., 2000, Vol. 14(5), pp. 585-595
  337. Xu, L.L., Shanmugam, N., Segawa, T., Sesterhenn, I.A., McLeod, D.G., Moul, J.W. & Srivastava, S. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. Genomics, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814-4799, USA., 2000, Vol. 66(3), pp. 257-263
  338. Yamada, T., Takaoka, A.S., Naishiro, Y., Hayashi, R., Maruyama, K., Maesawa, C., Ochiai, A. & Hirohashi, S. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Res, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan., 2000, Vol. 60(17), pp. 4761-4766
  339. Yamada, T., Yamazaki, H., Yamane, T., Yoshino, M., Okuyama, H., Tsuneto, M., Kurino, T., Hayashi, S.-I. & Sakano, S. Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells. Blood, Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. yamad@grape.med.tottori-u.ac.jp, 2003, Vol. 101(6), pp. 2227-2234
  340. Yamashita, T., Budhu, A., Forgues, M. & Wang, X.W. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res, Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA., 2007, Vol. 67(22), pp. 10831-10839
  341. Yan, S., Zhou, C., Zhang, W., Zhang, G., Zhao, X., Yang, S., Wang, Y., Lu, N., Zhu, H. & Xu, N. beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett, Laboratory of Cell and Molecular Biology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan, Chaoyang District, Beijing, PR China., 2008, Vol. 271(1), pp. 85-97
  342. Yang, X., Chen, M.-W., Terry, S., Vacherot, F., Bemis, D.L., Capodice, J., Kitajewski, J., de la Taille, A., Benson, M.C., Guo, Y. & Buttyan, R. Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells. Oncogene, Department of Urology, Columbia University Medical Center, New York, NY 10032, USA., 2006, Vol. 25(24), pp. 3436-3444
  343. Yang, Y., Wang, H.-C. & Sun, X.-H. Id1 induces apoptosis through inhibition of RORgammat expression. BMC Immunol, Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA. yuayang@utmb.edu, 2008, Vol. 9, pp. 20
  344. ichi Yasumoto, K., Takeda, K., Saito, H., ichi Watanabe, K., Takahashi, K. & Shibahara, S. Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling. EMBO J, Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba-ku, Sendai, Miyagi 980-8575, Japan., 2002, Vol. 21(11), pp. 2703-2714
  345. Yochum, G.S., Cleland, R. & Goodman, R.H. A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol, Vollum Institute and Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. yochumg@ohsu.edu, 2008, Vol. 28(24), pp. 7368-7379
  346. Yoon, J.W., Gilbertson, R., Iannaccone, S., Iannaccone, P. & Walterhouse, D. Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes. Int J Cancer, Developmental Biology Program, Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., 2009, Vol. 124(1), pp. 109-119
  347. Yoon, J.W., Kita, Y., Frank, D.J., Majewski, R.R., Konicek, B.A., Nobrega, M.A., Jacob, H., Walterhouse, D. & Iannaccone, P. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem, Northwestern University Medical School and Children's Memorial Institute for Education and Research, Chicago, Illinois 60614, USA., 2002, Vol. 277(7), pp. 5548-5555
  348. Yoshida, T., Tokunaga, A., Nakao, K. & Okano, H. Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation, Department of Physiology Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582, Japan., 2003, Vol. 71(8), pp. 486-495
  349. Young, C.Y., Andrews, P.E., Montgomery, B.T. & Tindall, D.J. Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein. Biochemistry, Department of Urology, Mayo Clinic/Foundation, Rochester, Minnesota 55905., 1992, Vol. 31(3), pp. 818-824
  350. Yu, M., Gipp, J., Yoon, J.W., Iannaccone, P., Walterhouse, D. & Bushman, W. Sonic hedgehog-responsive genes in the fetal prostate. J Biol Chem, University of Wisconsin Medical School, Molecular and Environmental Toxicology Center, Madison, Wisconsin 53705, USA., 2009, Vol. 284(9), pp. 5620-5629
  351. Yuan, D., Liu, L. & Gu, D. Transcriptional regulation of livin by beta-catenin/TCF signaling in human lung cancer cell lines. Mol Cell Biochem, Department of Thoracic Surgery, The Affiliated Hospital of Weifang Medical College, Weifang, Shandong Province 261031, PR China. yuandong72@yahoo.com.cn, 2007, Vol. 306(1-2), pp. 171-178
  352. Zeilstra, J., Joosten, S.P.J., Dokter, M., Verwiel, E., Spaargaren, M. & Pals, S.T. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., 2008, Vol. 68(10), pp. 3655-3661
  353. Zhai, Y., Wu, R., Schwartz, D.R., Darrah, D., Reed, H., Kolligs, F.T., Nieman, M.T., Fearon, E.R. & Cho, K.R. Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas. Am J Pathol, Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0638, USA., 2002, Vol. 160(4), pp. 1229-1238
  354. Zhang, T., Otevrel, T., Gao, Z., Gao, Z., Ehrlich, S.M., Fields, J.Z. & Boman, B.M. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res, Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA., 2001, Vol. 61(24), pp. 8664-8667
  355. Zhang, X.M., Ramalho-Santos, M. & McMahon, A.P. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell, Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA., 2001, Vol. 106(2), pp. 781-792
  356. bei Zhang, Y., min Chen, A., jing Guo, F., long Huang, S., hua Xiong, W. & Li, Q. [Regulation of differentiation and proliferation of epiphysis stem cells by Notch1 signaling system] Zhonghua Yi Xue Za Zhi, Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China., 2005, Vol. 85(48), pp. 3430-3434
  357. Zhou, C., Liu, S., Zhou, X., Xue, L., Quan, L., Lu, N., Zhang, G., Bai, J., Wang, Y., Liu, Z., Zhan, Q., Zhu, H. & Xu, N. Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. Int J Cancer, Laboratory of Cell and Molecular Biology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China., 2005, Vol. 113(6), pp. 891-898
  358. Zhu, H.-X., Zhang, G., Wang, Y.-H., Zhou, C.-Q., Bai, J.-F. & Xu, N.-Z. [Indomethacin induces apoptosis through inhibition of survivin regulated by beta-catenin/TCF4 in human colorectal cancer cells] Ai Zheng, Laboratory of Cell and Molecular Biology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R.China. xningzhi@public.bta.net.cn, 2004, Vol. 23(7), pp. 737-741
  359. Ziemer, L.T., Pennica, D. & Levine, A.J. Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene. Mol Cell Biol, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA., 2001, Vol. 21(2), pp. 562-574
  360. Zákány, J., Kmita, M., Alarcon, P., de la Pompa, J.L. & Duboule, D. Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland., 2001, Vol. 106(2), pp. 207-217